Asian Journal of Microbiology and Biotechnology

Metabolic diseases, including obesity, diabetes, cardiovascular disease and non-alcoholic fatty liver disease, are steadily on the rise worldwide, partly contributed by dietary habits and sedentary lifestyle as well as genetic conditions. Although conventional interventions are successful, they may be limited by side effects and the lack of long-term control. Increasing attention has recently been devoted to functional foods and nutraceuticals as potentially effective adjunctive modalities in the management of metabolic disorders. This review emphasises the interaction of functional foods (such as oats, berries, probiotics and green tea) and nutraceuticals (e.g., polyphenols, omega-3 fatty acids, vitamins, minerals, probiotics and herbals), with regard to changed glycemic status, lipid intervention, oxidative stress alleviation, and inflammatory potentiation via eubiosis in the gut microbiota composition. Mechanisms include better insulin signalling,  increased AMPK activity, lipid modulation and hepatoprotection. Novel methods such as hybrid formulations and newer delivery systems (e.g., nanoencapsulation, liposomal gels) enhance the bioavailability and therapeutic benefits. In spite of the promising evidence, standardisation, regulatory approval, clinical value and consumer reception constitute major obstacles. For the future, including personalised nutrition, precision medicine and microbiome-informed interventions are required to improve metabolic health. In conclusion, functional foods and nutraceuticals are a safe, natural, and sustainable way for the prevention and treatment of metabolic disorders.