Screening of Neuropharmacological Activities of Naringi crenulata (Roxb.) Nicolson Leaves

PDF

Published: 2023-08-23

DOI: 10.56557/ajmab/2023/v8i28351

Page: 93-110


Sinchu Yesudanam *

Mar Dioscorus College of Pharmacy, Thiruvananthapuram, Kerala, India.

T. S. Sheeba Jasmin

College of Pharmaceutical Sciences, Govt. Medical College, Thiruvananthapuram, Kerala, India.

*Author to whom correspondence should be addressed.


Abstract

Purpose: Although the global prevalence of psychological disorders is increasing continually, the efficacies of therapeutic strategies are still very limited. Oxidative stress has been implicated in the pathogenesis of psychiatric disorders and substances possessing antioxidant activity can alleviate the mentioned conditions. Therefore, we hypothesized that Naringi crenulata (Roxb.) Nicolson leaves, a medicinal plant claimed for nerve tonic, also possess neuropharmacological activities which provide an advantage for psychiatric disorders.

Methods: The present study was carried out to perform neuropharmacological screening methods on sedatives and hypnotics (Phenobarbitone sodium-induced sleep latency and sleep time and Motor coordination activity), anxiolytics (elevated plus maze and open field test), anti-depressants (forced swim test and L-dopa induced hyperactive aggressive behaviour in mice) and anticonvulsants activities (PTZ and MES induced convulsions) in Swiss Albino mice and Sprague Dawley rats.

Results: The methanolic extract of a higher dose of Phenobarbitone sodium in Naringi crenulata induced sleep latency and sleep time significant results. The extracts of Naringi crenulata showed a significant dose-dependent increase in muscle relaxation in motor coordination activity. In the experiment of PTZ-induced convulsions, the latency of seizures was prolonged by the extracts in a dose-dependent manner. Even in MES-induced convulsion, the results were extremely significant for the 400mg/kg of MENC. The depressant effect was observed to be significant to the extracts of the herb in the Open Field test and also for the Elevated Plus Maze apparatus. In the Forced Swim Test, MENC (400 mg/kg) significantly lengthened the time spent immobile (p <0.01), indicating a CNS depressive impact. Lastly in L-dopa-induced hyperactive aggressive behaviour in mice, results suggest that NC has antidepressant efficacy due to its influence on the serotonergic, noradrenergic, and dopaminergic systems.

Conclusion: The methanolic extract of Naringi crenulata (Roxb.) Nicolson leaves showed significant neuroprotective activity. So, the extracts of Naringi crenulata can be used for the treatment of a wide variety of neurological ailments in humans.

Keywords: Naringi crenulata, methanolic extract, neuropharmacological activities


How to Cite

Yesudanam, S., & Jasmin, T. S. S. (2023). Screening of Neuropharmacological Activities of Naringi crenulata (Roxb.) Nicolson Leaves. Asian Journal of Microbiology and Biotechnology, 8(2), 93–110. https://doi.org/10.56557/ajmab/2023/v8i28351

Downloads

Download data is not yet available.

References

Murray CJ, Lopez AD. Alternative projections of mortality and disability by cause 1990-2020: Global Burden of Disease Study. Lancet. 1997;349(9064): 1498–1504.

Taylor DJ, Lichstein KL, Durrence HH. Insomnia as a health risk factor. Behav. Sleep Med. 2003;1(4):227–247.

Hsu MC, Creedy D, Moyle W, Venturato L, Tsay SL, Ouyang WC. Use of Complementary and Alternative Medicine among adult patients for depression in Taiwan. J.Affect. Disord. 2008;111(2-3): 360–365.

Kessler D, Bennewith O, Lewis G, Sharp D. Detection of depression and anxiety in primary care: Follow up study; 2002.

Subramanian Sampathkumar, Natesan Ramakrishnan. GC-MS analysis of Naringi crenulata (roxb.) nicols. Leaves. Asian Journal of Pharmaceutical and Clinical Research. 2011;4(4):146.

Kawalpreet Kaur, Deepak Kumar, Suresh Kumar. Screening of Neuropharmacological Activities of Calotropis gigantea roots. Journal of Pharmaceutical, Chemical and Biological Sciences. 2014;2(3):186-196.

Sirisha Chowdary G. Neuro pharmacological screening of ethanolic extract of Nelumbo nucifera Gaertner seeds. Indian journal of research in pharmacy and biotechnology. 2013;1(5): 635-642.

Philadelphia BV, Denzil Colaco, Imtiyaz Ansar. Evaluation of Skeletal Muscle Relaxant Activity of Ethanolic Extract of the Leaves of Costus pictus D. Don in Swiss Albino Mice. 2018;11(2):313.

Sachin Kumar Jain, Talever Singh, Milind Pandeand Nitin Nema. Neuropharmacological screening of fronds of Adiantum Capillus Veneris Linn. Scholars Research Library. 2014;6(3):167-175.

Apurba Sarker Apu, Shakhawat Hossan Bhuyan, Maima Matin. Analgesic, neuropharmacological, anti-diarrheal, and cytotoxic activities of the extract of Solanum sisymbriifolium (Lam.) leaves. 2013;3(4):302-312.

Sarwar MD. Rashidur Rahman, Kamrun Nahar, Muhammad Ashikur Rahman. Analgesic and neuropharmacological activities of methanolic leaf extract of Clitoria ternatea Linn. Journal of pharmacognosy and phytochemistry. 2014;2(5):110-114.

Alamgeer, Muhammad Nasir Hayat Malik, Muhammad Naveed Mushtaq. Evaluation of some Central Nervous System (CNS) activities of aqueous methanolic extract of Paspalidium flavidum Linn. Journal of Medicinal Plants Research. 2012;6(16): 3222-3227.

Suresh D, Mathu M, Saritha CH. Anti depressant activity of Spirulina platensis in experimentally induced depressed mice. International journal of Pharmaceutical Archive. 2014;3 (2):317-326.

Kulkarni SK. Handbook of experimental Pharmacology. New Delhi, Academic Press. 2010;3:20.

Hemamalini K, Uma Vasireddy, Rathna Sundari E. Anticonvulsant and sedative effects of leaf extract of Gymnosporia emerginata. International Journal of Research in Pharmacy and Science. 2013; 3(2):154-160.

Randa Hilal-Dandan, Bjorn Knoliman, Laurence Brunton. Goodman and Gilman’s the Pharmacological basis of Therapeutics. New York, Academic Press. 2018;13(362):1464 and1501.

Vogel HG, Vogel WH. Drug Discovery and Evaluation. Berlin, Heidelberg, New York: Springer-Verlag. 2002;2:689-742.

Rajasekaran M, Kalaichelvan S. Antioxidative Role of Costus pictus D.DON in Hyperglycemic Rats administered with Alloxon. Journal of Pharmaceutical Sciences and Research. 2014;6(1):24–28.

Velmurugan V, Arunachalam G, Ravichandran V. International Journal of Pharm Tech Research. 2002;4(1):89- 92.

Katiyar C, Kumar A, Bhattacharya SK, Singh RS. Journal of Advances in Drug Research. 2010;81:190-195.

Pushpa KB, Mahipal RR, Menasa VB. Journal of Advances in Drug Research. 2010;1(1):1-9.

Karen Whalen. Lippincott illustrated reviews: Pharmacology. Academic Press. 2019;7:701 and 247.

Oktay M, Gulcin I, Kufrevioglu OI. Determination of in vitro antioxidant activity of fennel (Foeniculumvulgare) seed extracts. Leb-Wissen Technol. 2003;36: 263-71.

Sarwar MD, Rashidur Rahman, Kamrun Nahar, Muhammad Ashikur Rahman. Analgesic and neuropharmacological activities of methanolic leaf extract of Clitoria ternatea Linn. Journal of Pharmacognosy and phytochemistry. 2014;2(5):110-114.

Alamgeer, Muhammad Nasir Hayat Malik, Muhammad Naveed Mushtaq. Evaluation of some Central Nervous System (CNS) activities of aqueous methanolic extract of Paspalidium flavidum Linn. Journal of Medicinal Plants Research. 2012;6(16): 3222-3227.

Sachin Kumar Jain, Talever Singh, Milind Pandeand Nitin Nema. Neuropharmacological screening of fronds of Adiantum Capillus Veneris Linn. Scholars Research Library. 2014;6(3):167-175.

Gadekar DH, Sourabh J, Jitender MK. Evaluation of anxiolytic activity of Boerhaavia diffusa hydro-alcoholic extract of leaves in rats. Int Res J Pharm. 2011;2:90-92.

Maes M, Meltzer HY. The serotonin hypothesis of major depression. In: Bloom FE, et al, editor. Psychopharmacology: The third generation of progress. New York: Raven Press. 1995;993–1044.

Anderson IM. SSRIs versus tricyclic antidepressants in depressed inpatients: A metaanalysis of efficacy and tolerability. Depress Anxiety. 1998;7:11– 7.

Ozawa H, Miyauchi T, Sugawara K. Potentiating effect of lithium chloride on aggressive behaviour induced in mice by nialamide plus L-DOPA and clonidine. Eur J Pharmacol. 1975;34:169–79.

Serra G, Collu M, D’Aquila PS, De Montis GM, Gessa, GL. Possible role of dopamine D1 receptor in the behavioural supersensitivity to dopamine agonists induced by chronic treatment with antidepressants. Brain Res. 1990;527(3): 234–43.