Prevalence of Carbapenem Resistant Enterobacteriaceae Isolates among Pregnant Women of Rural Areas from Dehradun, Uttarakhand, India
Vishal Sawarn
Doon (P.G.) Paramedical College and Hospital, 28, Chakrata Road, Dehradun, Uttarakhand-248001, India.
Aprna Uniyal
Doon (P.G.) Paramedical College and Hospital, 28, Chakrata Road, Dehradun, Uttarakhand-248001, India.
Rajeev Kumar Gautam *
Department of Microbiology, Doon (P.G.) Paramedical College & Hospital, Dehradun, Uttarakhand, India.
*Author to whom correspondence should be addressed.
Abstract
The aim of the study is to determine the prevalence and antimicrobial resistance patterns of carbapenem-resistant Enterobacteriaceae isolated from pregnant women in rural areas of Dehradun, Uttarakhand, India. During this study, 250 clinical samples were gathered 88 from the outpatient and 162 from the inpatients side. Along the way, researchers identified 110 gram-negative bacilli from the Enterobacteriaceae group using Gram’s stain, negative stain, and the standard biochemical tests. A phenotypic detection was done by the Modified Hodge test and Imp-EDTA disk synergy test. Interestingly, these findings generally match earlier work, which points out that specimen types - blood, sputum, pus, urine, or bronchoalveolar lavage—often show quite a bit of variability. In this sample set, the bacteria turned out to be 60 Escherichia coli, 29 Klebsiella pneumoniae, 13 Pseudomonas aeruginosa, and 8 Proteus mirabilis, underscoring a diverse picture of infections. The objective of the study is to determine the prevalence of Carbapenem Resistant Enterobacteriaceae among pregnant women in rural areas of Dehradun, Uttarakhand, India. Rural Dehradun presents unique conditions that justify focused research: limited healthcare infrastructure, high antibiotic misuse due to over-the-counter access, poor sanitation and lack of routine microbial screening during pregnancy. Overall, this spread highlights why keeping an ongoing, careful watch and making spot-on identifications is so important, both in outpatient and inpatient settings, to guide effective antimicrobial therapy.
Keywords: GNB- Gram negative bacteria, CRE- Carbapenem Resistant Enterobacteriaceae, MBL- Metallo-β-lactamases