QUANTITATIVE ANALYSIS OF SOME BRANDS OF DICLOFENAC MARKETED IN MAIDUGURI METROPOLIS, USING ULTRA VIOLET SPECTROPHOTOMETRY AND HIGH PERFORMANCE LIQUID CHROMATOGRAPHIC METHODS

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Published: 2015-04-22

Page: 191-201


ALI AUDU SANI *

Department of Chemistry, Faculty of Science, Federal University Dutse, Dutse, Nigeria

AISHA IBRAHIM MASAYA

Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Maiduguri, Maiduguri, Nigeria

SALISU NASIR

Department of Chemistry, Faculty of Science, Federal University Dutse, Dutse, Nigeria

ABDU HARUNA KAITA

Department of Pharmaceutical and Medicinal Chemistry, Faculty of Pharmaceutical Sciences, Ahmadu Bello University, Zaria, Kaduna, Nigeria

MOHAMMED ILYAS

Department of Pharmaceutical and Medicinal Chemistry, Faculty of Pharmaceutical Sciences, Ahmadu Bello University, Zaria, Kaduna, Nigeria

*Author to whom correspondence should be addressed.


Abstract

The quantitative analysis of different brands of Diclofenac tablets was carried out (using HPLC and U.V spectrophotometric method) to determine if the drugs are of required standards. The results obtained from analysis of the various drugs were compared with that of the standard. The percentage content for each sample was calculated using the absorbance and peak areas of the samples and that of the standard to see if they are within the specified limit as stated by the official books. Diclofenac has a range of 95.0%-105% as stated by B. P 2008, UV result shows that 5 samples of the drug passed and 5 failed while for HPLC, only 1 sample passed.

 

Keywords: Diclofenac tablets, UV, HPLC


How to Cite

SANI, A. A., MASAYA, A. I., NASIR, S., KAITA, A. H., & ILYAS, M. (2015). QUANTITATIVE ANALYSIS OF SOME BRANDS OF DICLOFENAC MARKETED IN MAIDUGURI METROPOLIS, USING ULTRA VIOLET SPECTROPHOTOMETRY AND HIGH PERFORMANCE LIQUID CHROMATOGRAPHIC METHODS. Journal of Applied Chemical Science International, 2(4), 191–201. Retrieved from https://ikprress.org/index.php/JACSI/article/view/2913

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