SOLUBILITY OF TETRAHYDROPYRIMIDINE DERIVATIVES IN SOME SOLVENTS AT DIFFERENT TEMPERATURES
SHIPRA BALUJA *
Department of Chemistry, Physical Chemical Laboratory, Saurashtra University, Rajkot, India
ASHISH PATEL
Department of Chemistry, Physical Chemical Laboratory, Saurashtra University, Rajkot, India
KAPIL BHESANIYA
Department of Chemistry, Physical Chemical Laboratory, Saurashtra University, Rajkot, India
*Author to whom correspondence should be addressed.
Abstract
Solubility of some tetrahydropyrimidine derivatives have been studied in methanol, ethanol, iso-propyl alcohol and tetrahydrofuran at different temperatures (293.15 to 313.15 K) at atmospheric pressure. For all compound, solubility increase with increase in temperature and found to be higher in THF than other selected alcoholic solvents. Further, some thermodynamic parameters such as enthalpy, Gibb’s free energy and entropy of dissolution have been evaluated from solubility data. For all the compounds, enthalpy and Gibb’s free energy values are positive whereas entropy values are negative for some compounds.
Keywords: Tetrahydropyrimidine derivatives, solubility, alcohols, tetrahydrofuran, thermodynamic parameters