THE PRODUCTION AND BLOW FILL SEAL TECHNOLOGY OF WATER FOR INJECTION
ARCHANA ZALA *
Central University of Gujarat, School of Chemical Sciences, Industrial Chemistry, Sector 30, Gandhinagar – 382030, India
*Author to whom correspondence should be addressed.
The aim of this article is to investigate production and production technology of water for injection (WFI). Water for injection is a worldwide commercial product. Water for Injection is used in production of parenteral drugs and other preparations where endotoxin content of product must be controlled. Pharmaceutical applications of WFI are Raw material for manufacturing, Cell culture, Chromatography, Process validation, Device processing, Purification buffers, DNA/RNA purification, a diluents drugs or medicine production, cleaning of certain equipment and parenteral product-contact components. There is a large market for medical and pharmaceutical world. The Pre-filtration, Additives, Softeners, Deionization, Reverse Osmosis, Distillation and filtration are stages of conversation well water to RO water. Unit process and unit operations are discussed for production of water for injection. Blow Fill Seal Technology (BFS Technology) is widely use for final product. The process is constantly undergoing research and development to optimize the process technology and its components, ultimately producing better quality end products.
Keywords: Water for injection, blow fill seal technology, the production of water for injection, unit operations