CHEMICAL AND MINERALOGICAL CHARACTERIZATION AND ANTI-INFLAMMATORY ACTIVITY EVALUATION OF SENEGAL’S MUDS

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Published: 2017-11-22

Page: 95-105


ROKHAYA SYLLA GUEYE *

Laboratory of Organic and Therapeutic Chemistry, Faculty of Medicine, Pharmacy and Odontology (F.M.P.O.), Cheikh Anta Diop University of Dakar (U.C.A.D.) PB 5005, Dakar-Fann, Sénégal.

AWA NDIAYE SY

Laboratory of Pharmacology and Pharmacodynamics, (F.M.P.O.), Cheikh Anta Diop University of Dakar (U.C.A.D.) PB 5005, Dakar-Fann, Sénégal.

INSA BADIANE

Laboratory of Chemistry and Physics of Materials, Assane Seck University of Ziguinchor (U.A.S.Z.), PB 523, Sénégal.

MOUHAMADOU BASSIR DIOP

Laboratory of Geomaterials, Earth Sciences Institut (I.S.T.), Cheikh Anta Diop University of Dakar (U.C.A.D.), PB 5005, Dakar-Fann, Sénégal.

CHEIKH SALL

Laboratory of Chemistry, Formation and Unit Resarch, Thies University (U.T.), PB 967, Sénégal.

MAMADOU BALDE

Laboratory of Organic and Therapeutic Chemistry, Faculty of Medicine, Pharmacy and Odontology (F.M.P.O.), Cheikh Anta Diop University of Dakar (U.C.A.D.) PB 5005, Dakar-Fann, Sénégal.

MADIEYE SENE

Laboratory of Pharmacology and Pharmacodynamics, (F.M.P.O.), Cheikh Anta Diop University of Dakar (U.C.A.D.) PB 5005, Dakar-Fann, Sénégal.

YOUSSOU NDAO

Laboratory of Galenic and Legislation, (F.M.P.O.), Cheikh Anta Diop University of Dakar (U.C.A.D.). PB 5005, Dakar-Fann, Sénégal.

ADAMA DIEDHIOU

Laboratory of Organic and Therapeutic Chemistry, Faculty of Medicine, Pharmacy and Odontology (F.M.P.O.), Cheikh Anta Diop University of Dakar (U.C.A.D.) PB 5005, Dakar-Fann, Sénégal.

GUATA YORO SY

Laboratory of Pharmacology and Pharmacodynamics, (F.M.P.O.), Cheikh Anta Diop University of Dakar (U.C.A.D.) PB 5005, Dakar-Fann, Sénégal

MATAR SECK

Laboratory of Organic and Therapeutic Chemistry, Faculty of Medicine, Pharmacy and Odontology (F.M.P.O.), Cheikh Anta Diop University of Dakar (U.C.A.D.) PB 5005, Dakar-Fann, Sénégal.

DJIBRIL FALL

Laboratory of Organic and Therapeutic Chemistry, Faculty of Medicine, Pharmacy and Odontology (F.M.P.O.), Cheikh Anta Diop University of Dakar (U.C.A.D.) PB 5005, Dakar-Fann, Sénégal.

ALASSANE WELE

Laboratory of Organic and Therapeutic Chemistry, Faculty of Medicine, Pharmacy and Odontology (F.M.P.O.), Cheikh Anta Diop University of Dakar (U.C.A.D.) PB 5005, Dakar-Fann, Sénégal.

*Author to whom correspondence should be addressed.


Abstract

Clays have been use in therapeutics for a long time and proliferation of thermal mud centers testifies to its effectiveness. In our work, anti-inflammatory activity of Ziguinchor mangrove sludge and Mbodiène attapulgite was evaluated, after a chemical and mineralogical characterization. Results obtained showed for mangrove mud multiple components with mainly varying contents in sodium, aluminum, chlorine, silicon and iron. Attapulgite was predominantly composed of silicon 55.15%, magnesium 13.8%, calcium 11.11%, iron 8.3% and aluminum 7.78%. The cation exchange capacity evaluated with the cobaltihexamine ion was 95 meq / 100 g for Attapulgite versus 6.85 meq / 100 g for the mangrove mud. Mineralogical analysis has shown that mangrove mud consists essentially of kaolinite and palygorskite is the dominant mineral of attapulgite with quartz, crystals of ankerites, dolomites. Anti-inflammatory activity evaluation showed a percentage of inhibition of edema induced in croton oil from 25.23% for attapulgite, to 28.34% for Ziguinchor mud, against 52, 26% for Voltaren Emulgel® as reference. These results predict a good way of additional treatment at lower cost for pathologies such as osteoarthritis.

Keywords: Clays, mudflat, attapulgite, antiinflammatory activity


How to Cite

GUEYE, R. S., SY, A. N., BADIANE, I., DIOP, M. B., SALL, C., BALDE, M., SENE, M., NDAO, Y., DIEDHIOU, A., SY, G. Y., SECK, M., FALL, D., & WELE, A. (2017). CHEMICAL AND MINERALOGICAL CHARACTERIZATION AND ANTI-INFLAMMATORY ACTIVITY EVALUATION OF SENEGAL’S MUDS. Journal of Applied Chemical Science International, 8(3), 95–105. Retrieved from https://ikprress.org/index.php/JACSI/article/view/3819

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