Journal of Applied Chemical Science International

SYNTHESIS OF SOME CONDENSED 2-(6-iodo-4-oxoquinazolin-3(4H)-yl)acetohydrazide

MAHER A. EL-HASHASH

Department of Chemistry, Faculty of Science, Ain Shams University, Cairo, Egypt

HADEER M. BAKEER

Department of Chemistry, Faculty of Science, Fayoum University, Fayoum, Egypt

IBRAHIM E. EL-SHAMY *

Department of Chemistry, Faculty of Science, Fayoum University, Fayoum, Egypt

ABDALLA O. ABDEL AZIZ

Department of Chemistry, Faculty of Science, Fayoum University, Fayoum, Egypt

*Author to whom correspondence should be addressed.

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Abstract

A highly efficient and versatile synthetic approach to the synthesis of some new condensed 2-(6-iodo-4-oxoquinazolin-3(4H)-yl)acetohydrazide viz. 1,2,4-triazolyl- 11, 1,3,4-oxadiazolyl- 8a,b, 9, 1,3,4-thiadiazolyl- 12, and pyrazolylquinazolinone derivatives 13-15 is presented. Moreover, acyclo C-nucleoside 17 were obtained via heterocyclization reaction of 2-(6-iodo-4-oxoquinazolin-3(4H)-yl)acetohydrazide (3) with D-glucono-1,5-lactone. Spectral (IR, ¹H NMR, ¹³C NMR) data, and elemental analyses confirmed the structures of the newly synthesized compounds.

Keywords: Quinazolinone, acyclo C-nucleoside, 1,3,4-thiadiazole, 1,2,4-triazole

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