SYNTHESIS AND CHARACTERIZATION OF MULTI-RESPONSIVE NANO-SIZED HYDROGEL BASED ON N-ISOPROPYLACRYLAMIDE AND MAGNETITE

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Published: 2016-03-22

Page: 132-140


V. V. KONOVALOVA *

Department of Chemistry, National University of Kiev-Mohyla Academy, 2 Skovoroda Street, Kiev, 04655, Ukraine

YU. M. SAMCHENKO

Department of Science, Institute of Biocolloidal Chemistry, National Academy of Sciences of Ukraine, 42 Acad. Vernadsky Av, Kiev, 03142, Ukraine

S. O. KRYKLYA

Department of Science, Institute of Biocolloidal Chemistry, National Academy of Sciences of Ukraine, 42 Acad. Vernadsky Av, Kiev, 03142, Ukraine

S. M. SCHERBAKOV

M. G. Kholodny Institute of Botany, National Academy of Sciences of Ukraine, 2, Tereshchenkivska st., 01601, Kyiv, Ukraine

A. F. BURBAN

Department of Chemistry, National University of Kiev-Mohyla Academy, 2 Skovoroda Street, Kiev, 04655, Ukraine

Z. R. ULBERG

Department of Science, Institute of Biocolloidal Chemistry, National Academy of Sciences of Ukraine, 42 Acad. Vernadsky Av, Kiev, 03142, Ukraine

*Author to whom correspondence should be addressed.


Abstract

Multi-responsive nano-sized hydrogel composites based on N-isopropylacrylamide, acrylic acid, and magnetite have been synthesized and characterized using transmission electron microscopy (TEM), and dynamic light scattering (DLS) methods. It was shown that the average size of the synthesized nanoparticles are approximately 100 nm, and it depends on the temperature and pH value. Synthesized hydrogel nanoparticles purified by diafiltration have a clear phase transition between swollen and collapsed state when heated above 32°C or changing pH value below 4. Methylene Blue (photosensitizer for photodynamic therapy) was used as a model drug for release stadies. The release of Methylene Blue from nanogel was significantly accelerated at temperature above phase transition. This would allow the application of designed hydrogel nanoparticles for drug delivery systems, especially in cancer treatment.

Keywords: Thermosensitive nanogel, ferrogels, N-isopropylacrylamide, magnetite nanoparticles, TEM, DLS, controlled drug release


How to Cite

KONOVALOVA, V. V., SAMCHENKO, Y. M., KRYKLYA, S. O., SCHERBAKOV, S. M., BURBAN, A. F., & ULBERG, Z. R. (2016). SYNTHESIS AND CHARACTERIZATION OF MULTI-RESPONSIVE NANO-SIZED HYDROGEL BASED ON N-ISOPROPYLACRYLAMIDE AND MAGNETITE. Journal of Applied Chemical Science International, 6(3), 132–140. Retrieved from https://ikprress.org/index.php/JACSI/article/view/3983

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