SYNTHESIS AND BIOLOGICAL ACTIVITIES EVALUATION OF NEW SUBSTITUTED 1,2,4,8-TETRAAZASPIRO[4.5]DEC-2-ENES

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Published: 2018-02-28

Page: 144-152


HANY M. DALLOUL *

Department of Chemistry, Faculty of Applied Science, Alaqsa University, Gaza, Palestine

KHALED A. EL-NWAIRY

Ministry of Education and Higher Education, Beirut Street, Southern Remal, Gaza, Palestine

ALI Z. SHORAFA

Ministry of Education and Higher Education, Beirut Street, Southern Remal, Gaza, Palestine

AHMED S. ABU SAMAHA

Department of Biology, Faculty of Applied Science, Alaqsa University, Gaza, Palestine

*Author to whom correspondence should be addressed.


Abstract

A new series of 1,2,4,8-tetraazaspiro[4.5]dec-2-enes containing 1,2,4-triazole, piperidine and sulfonamide moieties have been synthesized from the reaction of 4-piperidone benzoylhydrazones having 1-methyl, 1-benzyl, and 1-isopropyl groups with appropriate nitrilimines. The microanalysis and spectral data (IR, 1H NMR, 13C NMR and MS) of the synthesized compounds are in full agreement with their molecular structure. The microbial features of the synthesized compounds were studied by a known method. Some of titled compounds exhibited significant antimicrobial activity on several strains of microbes.

Keywords: Antimicrobial activity, nitrilimines, sulfonamide, 1,2,4,8-tetraazaspiro[4.5]dec-2-ene


How to Cite

DALLOUL, H. M., EL-NWAIRY, K. A., SHORAFA, A. Z., & ABU SAMAHA, A. S. (2018). SYNTHESIS AND BIOLOGICAL ACTIVITIES EVALUATION OF NEW SUBSTITUTED 1,2,4,8-TETRAAZASPIRO[4.5]DEC-2-ENES. Journal of Applied Chemical Science International, 8(4), 144–152. Retrieved from https://ikprress.org/index.php/JACSI/article/view/4126

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