Main Article Content
The curative potentials of Costus afer on testosterone induced prostatitis and some biochemical parameters was investigated using rat models. Eighteen (18) male wistar rats were used. The rats were weighed and randomly separated into six (6) groups of 3 rats each and were induced with testosterone propionate (TP). The reference drug Centiflo XL (400mg) was used. Group I was not induced which served as control while group II rats were induced with TP without treatment. Group III rats were induced with TP and administered the standard drug. Group IV, V and VI were given the whole extract (100ml, 200ml and 300ml respectively). The administration, feeding, and housing lasted for twenty-eight (28) days. Qualitative phytochemical analysis of Costus afer revealed the presence of Flavonoids, Saponins, Phenols, Alkaloids, Cardiac Glycosides and the absence of Tanins. Results obtained show that the rats in group IV, V, and VI which were given Costus afer extract at different concentrations had decreased Prostrate specific antigen (PSA), testosterone, and Alkaline Phospatase (ALP) levels, while stress enzyme levels, Aspartate transaminase (AST) and Alanine transaminase (ALT) levels were elevated due to the presence of phenolic compounds in the whole extract of Costus afer. From this study, it can be said that the whole extract of Costus afer could be recommended as an effective drug in the treatment/management of Prostatitis.
Edeoga HO, Okoli BE. Chromosome Numbers of Costus lucanusianus (Costaceae) in Nigeria. Folia Geobotanica. 2000;35:315-318.
Iwu MM, Anyanwu BN. Phytotherapeutic profile of Nigerian herbs I: anti-inflammatory and anti-arthritic agents,” Journal of Ethnopharmacology; 1993.
Iwu MM. Handbook of African Medicinal Plants. Crc Press, London. 1993;161 –162.
Nwauche KT, Monago CC, Anacletus FC Antihyperglycemic activity of the aqueous extract of Costus afer stem alone and in combination with metformin. European Journal of Biotechnology and Bioscience. 2014;1 (5):19-25.
Nwauche KT, Anacletus FC, Ighorodje-Monago CC. Assessment of fatty Acid, proximate and Quantitative Phytochemical composition of matured stem of Costus afer (Bush cane). Journal of drug delivery and therapeutics. 2018;8(6):217-224.
Kalu EC, Ikewuchi CC, Ayalogu EO, Nwauche KT. Proximate and Phytochemical Profile of Melanthera biflora Leaves. International Journal of Biochemistry Research & Review. 2019;25(4):1-12.
Nwauche KT, Monago CC, Onwuka F. Management of Diabetic with Combined Therapy of Reducdyn and Metformin in Streptozotocin induced Diabetic Male Rats. Research Journal of Pharmacognosy and Phytochemistry. 2013;5(5):224-235.
Dokubo A, Okwudike AE, Nwauche KT. Changes in Antioxidant Markers and Histopathology of Wistar Rats Fed with Edible Clay (Nzu). Journal of Applied Life Sciences International. 2021;24(1):16-20.
Tripathi KD. Essential of medical pharmacology 4th Edition. Jaypee Brothers Medical Publishers Limited. New Delhi, India. 1999;432.
Catalona WJ, Richie JP, Hudson MA, Flanigan RC. Comparison of digital rectal examination and serum prostate specific antigen in the early detection of prostate cancer. The Journal of Urology. 1994;151(5):1283-90.
Varley H, Gownlook AH, Bell M. Practical Clinical Biochemistry. Heine mann Med. Books, London. 1980;(I):1078-1092.
Ukpabi CF, Agbafor KN, Ndukwe KO, Agwu A, Nwachukwu SN. Phytochemical composition of Costus afer Extract and its alleviation of carbon tetrachloride-induced Hepatic oxidative stress and Toxicity. International Journal of modern Botany. 2012;2(5):120-126.