OVEREXPRESSION STATUS OF ESTROGEN RECEPTOR, PROGESTERONE RECEPTOR AND HUMAN EPIDERMAL GROWTH FACTOR RECEPTOR 2 IN YOUNG FEMALE PATIENTS WITH BREAST CANCER FROM WESTERN ALGERIA
NESRINE M. MRABENT
Département de Biologie, UDL-SBA, Ex- ITMA, Sidi Bel Abbes, Algeria
HARIR NORIA *
Département de Biologie, UDL-SBA, Ex- ITMA, Sidi Bel Abbes, Algeria and Laboratoire de Microbiologie Moléculaire, Proteomics et Santé, Algeria
FERIEL SELLAM
Département de Biologie, UDL-SBA, Ex- ITMA, Sidi Bel Abbes, Algeria
SOUMIA ZEGGAI
Département de Biologie, UDL-SBA, Ex- ITMA, Sidi Bel Abbes, Algeria
ABDENACER TOU
Department of Pathology, Sidi bel Abbes University Hospital, Algeria
RACHIDA SALAH
Département de Biologie, UDL-SBA, Ex- ITMA, Sidi Bel Abbes, Algeria
MUSTAPHA DIAF
Département de Biologie, UDL-SBA, Ex- ITMA, Sidi Bel Abbes, Algeria
SORAYA MOULESSHOUL
Département de Biologie, UDL-SBA, Ex- ITMA, Sidi Bel Abbes, Algeria
*Author to whom correspondence should be addressed.
Abstract
Background: Breast cancer is a rare pathology among young women, however this disease is known for its aggressiveness as for its poor results.
Aims: The aim of our study was to assess the clinicopathological parameters of breast cancer in young Algerian women aged less than 40 years old; to determine the frequency of HER-2 (human epidermal growth factor receptor2) and to study its correlation with various clinico-pathological features.
Materials and Methods: Our samples were collected from the period of January 2008-December 2013; all of them were cases of mastectomy specimens of breast carcinoma. We used immunohistochemistry to evaluate the expression of HER-2, ER (estrogen receptor), and PR (progesterone receptor).
Results: 119 mastectomy specimens were received, HER-2 receptor was found positive in 34 of our female patients (28,6%); this positivity was insignificantly associated with histopathological sub-type nor with the expression of ER/PR status or lymph node status (p>0.05). However a positive association was observed with the histological grade, and tumor size (p<0.05).
Conclusion: This study shows that young females with breast cancer over-express HER-2 protein.
Keywords: HER-2, ER, PR, clinical-pathological parameters, breast carcinoma, young women, Western Algeria