OVEREXPRESSION STATUS OF ESTROGEN RECEPTOR, PROGESTERONE RECEPTOR AND HUMAN EPIDERMAL GROWTH FACTOR RECEPTOR 2 IN YOUNG FEMALE PATIENTS WITH BREAST CANCER FROM WESTERN ALGERIA

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Published: 2015-10-27

Page: 137-143


NESRINE M. MRABENT

Département de Biologie, UDL-SBA, Ex- ITMA, Sidi Bel Abbes, Algeria

HARIR NORIA *

Département de Biologie, UDL-SBA, Ex- ITMA, Sidi Bel Abbes, Algeria and Laboratoire de Microbiologie Moléculaire, Proteomics et Santé, Algeria

FERIEL SELLAM

Département de Biologie, UDL-SBA, Ex- ITMA, Sidi Bel Abbes, Algeria

SOUMIA ZEGGAI

Département de Biologie, UDL-SBA, Ex- ITMA, Sidi Bel Abbes, Algeria

ABDENACER TOU

Department of Pathology, Sidi bel Abbes University Hospital, Algeria

RACHIDA SALAH

Département de Biologie, UDL-SBA, Ex- ITMA, Sidi Bel Abbes, Algeria

MUSTAPHA DIAF

Département de Biologie, UDL-SBA, Ex- ITMA, Sidi Bel Abbes, Algeria

SORAYA MOULESSHOUL

Département de Biologie, UDL-SBA, Ex- ITMA, Sidi Bel Abbes, Algeria

*Author to whom correspondence should be addressed.


Abstract

Background: Breast cancer is a rare pathology among young women, however this disease is known for its aggressiveness as for its poor results.

Aims: The aim of our study was to assess the clinicopathological parameters of breast cancer in young Algerian women aged less than 40 years old; to determine the frequency of HER-2 (human epidermal growth factor receptor2) and to study its correlation with various clinico-pathological features.

Materials and Methods: Our samples were collected from the period of January 2008-December 2013; all of them were cases of mastectomy specimens of breast carcinoma. We used immunohistochemistry to evaluate the expression of HER-2, ER (estrogen receptor), and PR (progesterone receptor).

Results: 119 mastectomy specimens were received, HER-2 receptor was found positive in 34 of our female patients (28,6%); this positivity was insignificantly associated with histopathological sub-type nor with the expression of ER/PR status or lymph node status (p>0.05). However a positive association was observed with the histological grade, and tumor size (p<0.05).

Conclusion: This study shows that young females with breast cancer over-express HER-2 protein.

Keywords: HER-2, ER, PR, clinical-pathological parameters, breast carcinoma, young women, Western Algeria


How to Cite

MRABENT, N. M., NORIA, H., SELLAM, F., ZEGGAI, S., TOU, A., SALAH, R., DIAF, M., & MOULESSHOUL, S. (2015). OVEREXPRESSION STATUS OF ESTROGEN RECEPTOR, PROGESTERONE RECEPTOR AND HUMAN EPIDERMAL GROWTH FACTOR RECEPTOR 2 IN YOUNG FEMALE PATIENTS WITH BREAST CANCER FROM WESTERN ALGERIA. Journal of International Research in Medical and Pharmaceutical Sciences, 6(3), 137–143. Retrieved from https://ikprress.org/index.php/JIRMEPS/article/view/1642

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