UNUSUAL HORMONAL OVERLAP SYNDROME: VAN WYK-GRUMBACH SYNDROME
ANNESH BHATTACHARJEE
Department of Medicine, King George’s Medical College, Lucknow, U.P, India
SHOBHIT SHAKYA
Department of Medicine, King George’s Medical College, Lucknow, U.P, India
MANISH GUTCH *
Department of Medicine, King George’s Medical College, Lucknow, U.P, India
PRAVEEN KUMAR RAO
Department of Medicine, King George’s Medical College, Lucknow, U.P, India
*Author to whom correspondence should be addressed.
Abstract
Hypothyroidism commonly results in a delayed sexual development in most of the affected children. The rare association of Isosexual Precocious Puberty with delayed bone age in children with longstanding untreated hypothyroidism is called Van Wyk-Grumbach syndrome (VWGS). Most cases of the syndrome have been reported in girls, including its first ever description by Van Wyk and Grumbach. We describe a case of an adolescent boy who presented with the above syndrome and its classical features.
Keywords: Van Wyk Grumbach syndrome, precocious puberty, hypothyroidism