THE REACTION MECHANISM STUDY OF CEFTRIAXONE AND PHENYLALANINE
HAKAN SEZGIN SAYINER *
Department of Medicine, Infectious Diseases, Adiyaman University, Adiyaman, Turkey
FATMA KANDEMIRLI
Department of Biomedical Engineering, Faculty of Engineering and Architecture, Kastamonu University, Kastamonu, Turkey
*Author to whom correspondence should be addressed.
Abstract
Interaction between ceftriaxone used in the most commonly antibiotics combination in Staphylococcal scalded skin (SSS) infections and phenylalanine that is one of carrier-mediated transport system in the blood-brain barrier. It was investigated whether interaction between phenyl alanine and ceftriaxone occur and this study was performed by using semi-empirical- Parameterization Method 6 (PM6). Quantum chemical calculations were used to analyze the formation of a peptide bond between phenylalanine and Ceftriaxone molecules. Both concerted and a stepwise and mechanism were considered. The energetic requirements for the stepwise and concerted were determined.
Keywords: Ceftriaone, phenylalanine, semi-empirical, PM6