THE ANTIOXIDANT DRUG “U-74389G” ATTENUATES THE MEAN CORPUSCULAR HEMOGLOBIN CONCENTRATION LEVELS DURING HYPOXIA REOXYGENATION INJURY IN RATS
C. ΤSOMPOS *
Department of Obstetrics and Gynecology, Mesologi County Hospital, Etoloakarnania, Greece
C. PANOULIS
Department of Obstetrics and Gynecology, Aretaieion Hospital, Athens University, Attiki, Greece
K. ΤΟUTOUZAS
Department of Surgery, Ippokrateion General Hospital, Athens University, Attiki, Greece
A. TRIANTAFYLLOU
Department of Biologic Chemistry, Athens University, Attiki, Greece
G. ΖOGRAFOS
Department of Surgery, Ippokrateion General Hospital, Athens University, Attiki, Greece
A. PAPALOIS
Experimental Research Centre ELPEN Pharmaceuticals, S.A. Inc., Co., Attiki, Greece
*Author to whom correspondence should be addressed.
Abstract
Background: The effect of the antioxidant drug “U-74389G” was examined on a rat model and particularly in an hypoxia - reoxygenation protocol. The effects of that molecule were studied hematologically using blood mean corpuscular hemoglobin concentration (MCHC) levels.
Methods: 40 rats of mean weight 231.87 g were used in the study. MCHC levels were measured at 60 min of reoxygenation (for groups A and C) and at 120 min of reoxygenation (for groups B and D). The drug U-74389G was administered only in groups C and D.
Results: U-74389G administration non-significantly decreased the MCHC levels by 0.95%±0.63% (p=0.11). Reoxygenation time non-significantly decreased the MCHC levels by 0.53%±0.64% (p=0.39). However, U-74389G administration and reoxygenation time together non-significantly decreased the MCHC levels by 0.69%±0.37% (P= 0.06).
Conclusions: Findings from this study suggest that U-74389G administration, reoxygenation time and their interaction have no effect on MCHC values. Although MCHC is a sensitive hematologic index; the result was not clinically important.
Keywords: Hypoxia, reoxygenation U-74389G, mean corpuscular hemoglobin concentration