INVESTIGATING THE CHANGE OF ACTION POTENTIAL WAVEFORMS BY PHARMACOLOGICAL INFUSION INTO L. terrestris

Purchase PDF

Published: 2017-10-31

Page: 49-58


KUN IL CHUNG

Provert Research Laboratory, 111 Charlotte Place Ste#100, Englewood Cliffs, NJ 07632, USA

JUNE WON JANG

Provert Research Laboratory, 111 Charlotte Place Ste#100, Englewood Cliffs, NJ 07632, USA

DANIEL J. HAN

Provert Research Laboratory, 111 Charlotte Place Ste#100, Englewood Cliffs, NJ 07632, USA

DAVID J. AHN

Provert Research Laboratory, 111 Charlotte Place Ste#100, Englewood Cliffs, NJ 07632, USA

CHRISTIE SED

Provert Research Laboratory, 111 Charlotte Place Ste#100, Englewood Cliffs, NJ 07632, USA

TAEHYUK KIM

Provert Research Laboratory, 111 Charlotte Place Ste#100, Englewood Cliffs, NJ 07632, USA

KEONHO ROH

Provert Research Laboratory, 111 Charlotte Place Ste#100, Englewood Cliffs, NJ 07632, USA

DAVID CHU

Provert Research Laboratory, 111 Charlotte Place Ste#100, Englewood Cliffs, NJ 07632, USA

TAEKYOUNG LEE

Provert Research Laboratory, 111 Charlotte Place Ste#100, Englewood Cliffs, NJ 07632, USA

JONGBIN LEE *

Provert Research Laboratory, 111 Charlotte Place Ste#100, Englewood Cliffs, NJ 07632, USA

*Author to whom correspondence should be addressed.


Abstract

With the advent of uncountable number of new technologies, in fact, more people has experiencing cases of nerve cord injuries. However, not an optimal animal model for nerve cord injuries has been documented using invertebrates. The study was designed to investigate the use of L. terrestris as a model for the treatment of spinal cord injuries and their follow-up monitoring. Using a telemetric system to record data, the pharmacological effects on action potential were assessed, while comparing with a negative control water on the waveforms. The impulse reactions of the earthworm were examined to varying voltages of electrical stimuli.

By comparing the Fast Fourier Transform, interpolation-foldagram and stabilization time from each waveform, it was suggested that the four drugs, Ibuprofen, Phenol, Benzocaine and Acetaminophen in this study had a characteristic trend in change of each parameters. According to the patterns derived from the waveforms, both the type and the amount of the substances had an effect on L. terrestris’ action potentials, though not statistically significant. The result showed that the parameters we measured could be proportional to the doses of drugs within a certain range of electric stimulation. This study might contribute to more in-depth understanding of action potential propagation and nerve cord injury, if it could be applied properly.

 

Keywords: Action potential, spinal cord injury, invertebrate animal model, pharmacological stimuli, telemetric system, nervous propagation


How to Cite

CHUNG, K. I., JANG, J. W., HAN, D. J., AHN, D. J., SED, C., KIM, T., ROH, K., CHU, D., LEE, T., & LEE, J. (2017). INVESTIGATING THE CHANGE OF ACTION POTENTIAL WAVEFORMS BY PHARMACOLOGICAL INFUSION INTO L. terrestris. Journal of International Research in Medical and Pharmaceutical Sciences, 12(2), 49–58. Retrieved from https://ikprress.org/index.php/JIRMEPS/article/view/3562

Downloads

Download data is not yet available.