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Published: 2021-07-08

Page: 46-58


Department of Pharmaceutics, Khalsa College of Pharmacy, Amritsar-143001, India.


Department of Pharmaceutics, Khalsa College of Pharmacy, Amritsar-143001, India.


Department of Pharmaceutics, Khalsa College of Pharmacy, Amritsar-143001, India.


Department of Pharmaceutics, Khalsa College of Pharmacy, Amritsar-143001, India.


Department of Medical Laboratory and Technology, Khalsa College of Pharmacy and Technology, Amritsar, Punjab, India.


Department of Pharmaceutics, Khalsa College of Pharmacy, Amritsar-143001, India.

*Author to whom correspondence should be addressed.


Reduced water solubility causes drugs to dissolve slowly and absorb poorly, leading to low bioavailability. Solubility is an important factor to consider during the design and research process because most medications are weakly acidic and weakly basic. Appropriate studies and techniques are required to improve drug solubility and thus bioavailability and therapeutic effects. This review briefly explores particle size reduction, inclusion complexes, co-solvency, microemulsion, spray drying, nanotechnology, and other solubility enhancement techniques, as well as a comparison study of techniques based on research study. In conclusion, even though all solubility enhancement techniques are effective and have the potential to improve solubility, they each have their own set of advantages and disadvantages. As a result, stating any technique is superior to another is unfeasible.

Keywords: Solubility, amorphous, spray drying, liquid crystalline nanoparticles, lyophilization.

How to Cite

CHEMBAN, S. A., KAUR, L., SINGH, G., DHAWAN, R., KAUR, N., & KAUR, N. (2021). TECHNIQUES FOR ENHANCING THE SOLUBILITY OF POORLY WATER-SOLUBLE DRUGS: A COMPARATIVE REVIEW. Journal of International Research in Medical and Pharmaceutical Sciences, 16(2), 46–58. Retrieved from


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