Full Article - PDF

Published: 2021-12-13

Page: 55-63


Pharmaceutical Regulatory Affairs, JSS College of Pharmacy, JSS Academy of Higher Education, Mysuru, India.


MAX Super Speciality Hospital, Saket, New Delhi, India.


Sanskar College of Pharmacy and Research, Ghaziabad, India.


Pharmaceutical Regulatory Affairs, JSS College of Pharmacy, JSS Academy of Higher Education, Mysuru, India.

*Author to whom correspondence should be addressed.


The majority of today’s drug delivery systems are made of bio-degradable, biocompatible and natural bio-polymers, and they can administer drugs at controlled rate. Currently, many research efforts are being made on oral sustained drug delivery system, which is a solid dosing approach. Researchers produced a number of controlled-release and sustained-release dosage formulations by encasing the drug in natural polymer and forming a gel. Micro-beads are characterized as the monolithic sphere that is disseminated throughout the matrix as a molecular dispersion of particle. Esomeprazole microcapsules can also be formulated. Esomeprazole is a drug that is used for treating stomach and esophageal issues (like acid reflux, ulcers). It shows action by lowering the quantity of acid produced by your stomach. It helps symptoms like heartburn, swallowing difficulties, and a persistent cough. This medicine aids in the healing of acid damage to the stomach and esophagus, the prevention of ulcers, and the prevention of esophageal cancer. Proton pump inhibitors (PPIs), such as esomeprazole, are a type of medication. OTC esomeprazole products are used to treat frequent heartburn if you are self-treating with this drug (occurring 2 or more days a week). These medications do not alleviate heartburn immediately away because they take 1 to 4 days to take full action. This review gives information about the methods of preparation and evaluation of esomeprazole microcapsules, along with its advantages and disadvantages.

Keywords: Microcapsules, esomeprazole, proton pump inhibitor, micro beads, heartburn

How to Cite

VERMA, V., THAKUR, N., SIMRAN, ., & V., B. (2021). ESOMEPRAZOLE MICROCAPSULES: A REVIEW. Journal of International Research in Medical and Pharmaceutical Sciences, 16(3), 55–63. Retrieved from


Download data is not yet available.


Yadav RK, Satyam Prakash, Yadav K, Yadav NK, Mostafa M. Physico-chemical evaluation of Gastro retentive ranitidine hydrochloride: An anti-ulcer drug. Janaki Medical College Journal of Medical Science; 2016.

Mohanad Bashari, Pei Wang, Ahmed Eibaid, Yaoqi Tian, Xueming Xu, Zhengyu Jin. Ultrasound-assisted dextranase entrapment onto Ca-alginate gel beads. Ultrasonics Sonochemistry; 2013.

Seidy Pedroso-Santana, Noralvis Fleitas-Salazar. Ionotropic gelation method in the synthesis of nanoparticles/microparticles for biomedical purposes. Wiley Online Library; Jan 2020

Tropical Journal of Pharmaceutical Research (

Mokhtari S, Jafari SM, Assadpour E. Development of a nutraceutical nano-delivery system through emulsification/internal gelation of alginate, Food Chemistry; 2017. DOI: j.foodchem.2017.02.071 Available:

Ralph-Steven Wedemeyer, Henning Blume. Pharmacokinetic Drug Interaction Profiles of Proton Pump Inhibitors: An Update, Published online 2014 Feb 19. DOI: 10.1007/s40264-014-0144-0

Mitulkumar A. Patel, Mohamed HH. Abou Ghaly, Jacqueline V. Schryer-Praga, Keith Chadwick. The effect of ionotropic gelation residence time on alginate cross-linking and properties. Carbohydrate Polymers. 2 January 2017;155:362-371.

Weitong Sun, Yu Zou, Yaping Guo, Lu Wang, Xue Xiao, Rui Sun, Kun Zhao. Construction and characterization of curcumin nanoparticles system. Journal of Nanoparticle Research; 2014.

Ionotropic Gelation and Polyelectrolyte Complexation Technique: Novel Approach to Drug Encapsulation. Handbook of Encapsulation and Controlled Release; 2015.

Jong-Suep Baek, Eng Wan Yeo, Yin Hao Lee, Nguan Soon Tan, Say Chye Joachim Loo. Controlled-release nanoencapsulating microcapsules to combat inflammatory diseases, Published online 2017 Jun 8. DOI: 10.2147/DDDT.S133344

Leonardo MB. Ferreira, Charlene P. Kiill, Liliane N. Pedreiro, Aline M. Santos, Maria Palmira D. Gremião. Supramolecular design of hydrophobic and hydrophilic polymeric nanoparticles. Elsevier BV; 2018.

International Journal of Pharmacy and Pharmaceutical Sciences (

YuxiaoWang,ChenTan,SeyedMohammadDavachi,PeilongLi,PhilipDavidowsky,BingYan.Development of microcapsules using chitosan and alginate via W/O emulsion for the protection of hydrophilic compounds by comparing with hydrogel beads. Macromolecules. April 2021;30.

Yuti Tian, Yong Liu, Li Zhang, Quanxian Hua, Li Liu, Baoming Wang, Jianwei Tang. Preparation and characterization of gelatin-sodium alginate/paraffin phase change microcapsules. Aspects. February 2020;5.

Chowdary KPR. Controlled nifedipine release from microcapsules of its dispersions in PVP-MCC and HPC-MCC., Drug Development and Industrial Pharmacy, 5/1/1995 analysis.