MEDICINAL PLANTS FOR THE TREATMENT OF ALZHEIMER’S DISEASE: CURRENT TREATMENT & FUTURE PERSPECTIVE
AFREEN HASHMI
Amity Institute of Pharmacy, Amity University, Lucknow Campus, India.
VIVEK SRIVASTAVA
Amity Institute of Pharmacy, Amity University, Lucknow Campus, India.
PEEUSH SINGHAL
Department of Pharmaceutical Sciences, Gurukul Kangri (Deemed to be University), Haridwar, India.
*Author to whom correspondence should be addressed.
Abstract
Alzheimer's disease (AD) is a disorder of brain which progressively weakens the cognitive function. It is occur due to formation of β amyloid plaques & neurofibrillary tangles, & cholinergic neurotransmitter degeneration. At present there is no cure for this disease but currently it can be controlled by using a drugs which symptomatically treat the AD involve N-methyl D-aspartate (NMDA) receptor antagonist (memantine) & Acetylcholinesterase inhibitors (AChEIs) (donepezil, rivastigmine, galantamine). Natural treatment comprising various medicinal plants & herbs are utilize to treat brain disorders like dementia, amnesia, and AD from ancient time. Preclinical & clinical studies both are confirmed the therapeutic potential of herbal product for inhibition of AD. Medicinal plants shown effectiveness against Alzheimer’s probably because of their pleiotropic & multiple action which involves antioxidants, anti-inflammatory & neuroprotective activity. In this present review we focuses on the therapeutic potential of various medicinal plants which significantly contributed for treating AD & memory deficits.
Keywords: Medicinal plants, antioxidant, neuroprotective action, neurofibrillary tangles