ANTIFUNGAL AND HEMOLYTIC ACTIVITIES OF NEW SERIES OF NAPHTHOQUINONES DERIVATIVES

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Published: 2015-01-17

Page: 1-10


MOHAMMED NADJIB RAHMOUN *

Laboratory Antibiotics Antifungals: physical-chemistry, Synthesis and Biological Activity, Department of Biology, Faculty of Natural Sciences and Life Sciences, of the Earth and the Universe, BP119, Tlemcen University, Tlemcen 13000, Algeria

ZAHIA OTMANI- BOUCHERIT

Laboratory Antibiotics Antifungals: physical-chemistry, Synthesis and Biological Activity, Department of Biology, Faculty of Natural Sciences and Life Sciences, of the Earth and the Universe, BP119, Tlemcen University, Tlemcen 13000, Algeria

MOHAMED BENABDALLAH

Laboratory of Catalysis and Synthesis in Organic Chemistry, Department of Chemistry, Faculty of Science, BP119, Tlemcen University, Tlemcen 13000, Algeria

NOUREDDINE CHOUKCHOU- BRAHAM

Laboratory of Catalysis and Synthesis in Organic Chemistry, Department of Chemistry, Faculty of Science, BP119, Tlemcen University, Tlemcen 13000, Algeria

*Author to whom correspondence should be addressed.


Abstract

Naphthoquinones (NPQs) are compounds, which have diverse pharmacological properties including antiviral, antiinflammatory, antipyretic and anticancer activity. In this study, the antifungal and hemolytic activities of new series of NPQs derivatives were studied in vitro. The antifungal activity of these compounds was determined using the poisoned food technique against five filamentous fungi and hemolytic activity against human red blood cells (RBCs) by measuring the hemoglobin releasing. Compound 1a inhibit the mycelial growth of the all molds. This results is high than the structural analogue, lawsone. The compounds 1b and 1a were the less toxic against the RBCs. The di-ketone function in the position 2 and 4 of NPQs, amine group and electronegativity of substituants in the position C-2 and C-3 are necessary for the activity of NPQs. This suggests the involvement of the redox cycle in the center of theirs mechanism action. No correlation between the antimicrobial and cytotoxic activity was possible.

Keywords: Biological activity, lawsone, naphthoquinone, synthesis, toxicology


How to Cite

RAHMOUN, M. N., BOUCHERIT, Z. O.-., BENABDALLAH, M., & BRAHAM, N. C.-. (2015). ANTIFUNGAL AND HEMOLYTIC ACTIVITIES OF NEW SERIES OF NAPHTHOQUINONES DERIVATIVES. Journal of International Research in Medical and Pharmaceutical Sciences, 1(1), 1–10. Retrieved from https://ikprress.org/index.php/JIRMEPS/article/view/848

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