Formulating a Relief Lotion for Atopic Dermatitis
Jihye Lee *
Chemical Sciences Division, STEM Science Center, 111 Charlotte Place Ste#100, Englewood Cliffs, NJ 07632, USA.
*Author to whom correspondence should be addressed.
Abstract
Backround: Atopic dermatitis (AD), also called atopic eczema, is a common chronic skin condition with high prevalence, characterized by redness, inflammation, and itching. Especially when severe, AD can be highly disabling, causing significant physical and psychological problems. In the period of exponential increase in medication development, global-scale diseases like cancer, diabetes, and AIDS have received thorough care and substantial funding for research and therapy development. At the same time, non-transmittable illnesses such as atopic dermatitis have been considered minor in their impact. Various symptoms associated with AD could have detrimental effects on quality of life. This research of formulating a therapeutic AD lotion has been motivated to alleviate patients suffering from AD that may be characterized by scratchy dehydration, elevated skin sensitivity, and bacterial infection.
Methods: The ingredients, including aloe vera, glycerin, white petrolatum, bacitracin, lidocaine, evening primrose, pyrithione powder, borage seed oil, manuka honey, and vitamin D3, were meticulously selected based on the symptoms of atopic dermatitis. These ingredients were uniformly mixed, starting from an emulsified base lotion.
Results: Our data demonstrated that our main formulation and its derived groups showed more favorable properties for AD in relative stability, moisturization, and sensitivity than a commercial product. Further, its antibacterial strength was better than the eczema therapeutic cream. More clinical studies might be needed for further confirmation of the lotion quality.
Keywords: Atopic dermatitis, atopic lotion, dermal inflammation, eczema, emulsion formulation