BREAST CANCER IN SIDI BEL ABBES (WEST OF ALGERIA): CLINICOPATHOLOGICAL AND EPIDEMIOLOGICAL STUDY
ABBASSIA DEMMOUCHE *
Department of Biology, Biotoxicology Laboratory, Faculty of Natural Sciences and life-Djillali University Sidi Bel Abbes-Liabes, Algeria
F. BEDDEK
Department of Biology, Biotoxicology Laboratory, Faculty of Natural Sciences and life-Djillali University Sidi Bel Abbes-Liabes, Algeria and Central Laboratory of Biology, Hospital Establishment specializing in Obstetrics and Gynaecology, Sidi Bel Abbes, Algeria
S. RAHMANI
Central Laboratory of Biology, Hospital Establishment specializing in Obstetrics and Gynaecology, Sidi Bel Abbes, Algeria
A. H. MAI
Department of Biology, Biotoxicology Laboratory, Faculty of Natural Sciences and life-Djillali University Sidi Bel Abbes-Liabes, Algeria
*Author to whom correspondence should be addressed.
Abstract
Introduction: Breast cancer is the most common malignancy among Algerian Women and its incidence is rising. However, little information about their risk and prognostic factors is presently available.
Aim: This research has been performed to study breast cancer risk and prognostic factors in Sidi Bel Abbès (West of Algeria).
Materials and Methods: From 15 December 2012 until 15 April 2013, a prospective study on 213 patients with histological and/or cytological breast cancer diagnosis was developed. Patient information was obtained from Clinical Records and a questionnaire about risk factors was performed. Statistical Analysis was developed by means of Statview software, Student´s t Test and ANOVA were included.
Results: Breast cancer occurred in women with a mean age of 49.65±10.54 years, an average weight of 68.93±13.19 kg, menarche age at 13.58±1.57 years, with duration of breastfeeding of 10.58±9.14 months, oral contraceptive administration of 7.13±6.21 years, and menopause age at 44.97±7.02 years. According to TNM classification, 7.07% of tumors were T1, 42.42% T2, 10.1% T3, and 26.26% T4. 17.17% of tumors were M1, and 57.63% of tumors were M0. 2.92 % were in situ carcinoma. The most common histological type was infiltrating ductal carcinoma (83%). Most tumors were Grade II SBR (69%). Weight was positively associated with ER (P=0.01 or P<0.05) and Her2neu (P=0.03 or <0.05) levels.
Conclusion: This is the first research about breast cancer risk and prognostic factors developed in this area. It suggests that weight may be an important risk factor.
Keywords: Breast cancer, risk factors, prognostic factors