Effect of Ethanol Extract of Physalis angulata Roots on Some Liver Marker Enzymes in Male Wistar Albino Rats

Anita U. Nwankwo, Promise O. Oluka — Thu, 30 Nov 2023 00:00:00 +0000

While medicinal plants have garnered significant attention for their potential therapeutic applications in human diseases, the growing reliance on these plants in traditional medicine has raised concerns regarding their safety. This study seeks to evaluate the impact of the ethanol extract of Physalis angulata root on liver marker enzymes as a means of assessing its implications for liver health. Additionally, we present findings on the phytochemical composition and acute toxicity profile of the extract. Phytochemical screening confirmed the presence of alkaloids, glycosides, terpenoids, flavonoids, saponins, reducing sugars, and carbohydrates in the extract. The median lethal dose (LD50) was determined to be 316.23 mg/kg of body weight. Our data revealed statistically significant increases (p≤0.05) in the levels of aspartate amino transferase (AST) and total bilirubin in comparison to the untreated control group. Notably, a significant reduction (p≤0.05) in alanine amino transferase (ALT) levels was observed at a dose of 100 mg/kg body weight of the extract, while higher doses yielded an increase relative to the untreated control. There was also a significant increase (p≤0.05) in the level of total protein in groups treated with 100 mg/kg and 200 mg/kg of the extract, and no significant difference (p≤0.05) in the group treated with 200 mg/kg of the extract relative to the untreated control group. There was no significant difference (p≤0.05) observed in the levels of alkaline phosphatase (ALP) and albumin. In summary, our results indicate that the ethanol extract of Physalis angulata root exhibits dose-dependent toxicity, underscoring the importance of regulating the use of this plant in traditional medicine practices.

Consumer Protection Act, 2019: A Case Study

Bureddi Anudeep Venkata Sai, Deeksha K. S., Balamuralidhara V. — Sat, 25 Nov 2023 00:00:00 +0000

This article thoroughly summarizes the Consumer Protection Act CPA 2019, highlighting its crucial role in promoting fair trade, empowering consumers, and ensuring accountability in the pharmaceutical business and beyond.

The article delves into the CPA 2019's basic provisions, providing definitions for important terminology like "consumer," "consumer rights," and "product liability." It addresses the creation and duties of several consumer protection councils at the federal, state, and local levels, emphasizing their tasks as advisory bodies and advocates for consumer rights.

The article also discusses the idea of product liability, explaining the duties of producers, suppliers, and sellers of goods. To ensure a thorough understanding of this vital component of consumer protection, it explores exclusions and obligations in product liability proceedings.

The article concludes by discussing the legal structure surrounding offenses and punishments, particularly the severe consequences of infractions such as deceptive advertising, production and distribution of counterfeit or tainted goods, and noncompliance with orders requiring consumer dispute resolution. It also touches on the protection of activities conducted in good faith by the Act and the compounding of violations.

Journal of International Research in Medical and Pharmaceutical Sciences

Effect of Ethanol Extract of Physalis angulata Roots on Some Liver Marker Enzymes in Male Wistar Albino Rats

Consumer Protection Act, 2019: A Case Study