Journal of Case Reports in Medical Science https://ikprress.org/index.php/JOCRIMS <p><strong>Journal of Case Reports in Medical Science</strong> <strong>(ISSN: 2456-9143)</strong> aims to publish high quality case reports in all areas of Medical Science.</p> <p>The journal also encourages the submission of useful reports of negative results. This is a peer-reviewed, open access INTERNATIONAL journal. This journal follows OPEN access policy. All published articles can be freely downloaded from the journal website.</p> International Knowledge Press en-US Journal of Case Reports in Medical Science 2456-9143 A Case Report of Machado-Joseph Disease in Young Male Patient https://ikprress.org/index.php/JOCRIMS/article/view/8489 <p>Spinocerebellar ataxia type-3, also known as machado-joseph disease is an autosomal dominant CAG trinucleotide repeat disease that present in young to middle age adults.clinically, it is characterized by gradually progressive ataxia and progressive degenerative changes in cerebellum and spinal cord along with basal ganglia and cortex [1].</p> Shyam Patel Rajesh Khoiwal Copyright (c) 2024 Copyright I.K. Press. All rights reserved. 2024-01-17 2024-01-17 1 3 10.56557/jocrims/2024/v10i18489 A Rare Case Report of Herpes Simplex Virus Encephalitis and Herpes Zoster Skin Lesion: Its Diagnosis and Treatment https://ikprress.org/index.php/JOCRIMS/article/view/8774 <p>Herpes Simplex Virus (HSV) encephalitis and Herpes Zoster skin lesions are both caused by different strains of the herpes virus. Herpes Simplex Virus (HSV) encephalitis is caused by the Herpes Simplex Virus (HSV), typically HSV-1, while Herpes Zoster, commonly known as shingles, is caused by the Varicella-Zoster Virus (VZV), which is also a member of the herpesvirus family. This is a case report of HSVE with HZ in a 65 year’s old male patient admitted to hospital with chief complaints of erythematous fluid filled rash over abdomen since 1 week, two episodes of generalised type seizures involved all four limbs and with altered sensorium since 1 day. His past medical history revealed that he was a known case of pulmonary tuberculosis (PTB) 2 years ago and taken antitubercular therapy (ATT) for 6 months and also he had developed chickenpox in his childhood. The patient was diagnosed with herpes skin lesion and herpes simplex virus encephalitis based on his USG report and clinical, neurological symptoms respectively. His laboratory tests revealed abnormal haematology and LFT parameters, USG abdomen showed grade 1 fatty changes with hepatomegaly, echogenic sediments in urinary bladder and herpes zoster eruption in dermatomal distribution, chest X-ray showed suggestive sequalae of pulmonary Koch’s. the treatment was initiated with Acyclovir, Levetiracetam, Tramadol, etc.</p> Akshatha Bharathi Greeshma Raju S Vinod Naik Syed Mohammed Hussaini Copyright (c) 2024 Author(s). The licensee is the journal publisher. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. 2024-07-11 2024-07-11 4 10 10.56557/jocrims/2024/v10i18774 Acute Manic Episode and Psychosis as Early Manifestations of Systemic Lupus Erythematosus with Lupus Nephritis: A Case Report https://ikprress.org/index.php/JOCRIMS/article/view/8916 <p><strong>Background:</strong> Neurological and psychiatric conditions seen in SLE in the absence of other causes are broadly termed Neuropsychiatric SLE (NPSLE).</p> <p><strong>Case Presentation:</strong> This case report was of a 37-year-old, separated female Banker who presented initially with symptoms of mania with psychosis at the Psychiatry Department. She was initially managed as such but represented again with similar symptoms in addition to fluffy brownish hair with hair loss, and hyper-pigmented patches along the bridge of her nose, glabella, and zygomatic regions, extending to the ears and retro auricular region. Annular hypo-pigmentation, atrophic patches were also observed on the extensor surface of both forearms. She developed fever, and epigastric tenderness with several episodes of vomiting and diarrhea which were initially non-bloody at 48hrs into admission on account of which she was placed on antibiotics. The patient improved significantly after which she discharged herself against medical advice however represented 2 days after with a worsened condition. Proactive management was ensured with some sessions of hemodialysis. An assessment of acute flare of systemic lupus erythematosus SLE, precipitated by sepsis was made and was managed as such. The patient recovered tremendously and was discharged to the clinic.</p> <p><strong>Conclusion: </strong>The need for comprehensive examinations and investigations in this regard to exclude other differentials cannot be jettisoned. In this case, it could be said that the psychiatric symptoms came before the obvious signs of SLE, however, it is still possible to think of these symptoms as early signs of SLE or SLE aggravating an underlying mental disorder.</p> Oluwafunbi Opadola Babatunde Suleiman Michael Israel Samson Ojedokun Olaitan Oladele Adebayo Adekunle Copyright (c) 2024 Author(s). The licensee is the journal publisher. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. 2024-10-26 2024-10-26 11 17 10.56557/jocrims/2024/v10i18916 A Case Report of a Suspected Neonatal Alloimmune Thrombocytopenia in a Tertiary Health Institution https://ikprress.org/index.php/JOCRIMS/article/view/8930 <p>Fetal and neonatal alloimmune thrombocytopenia FNAIT is the leading cause of severe thrombocytopenia in the fetus and neonate leading to serious bleeding, intracranial haemorrhage and death and also intracranial haemorrhage in full-term infants.</p> <p>We reported a case of a 33-year-old woman who was delivered of a male neonate via Emergency lower segment Cesarean section CS on account of premature rupture of the membrane with oligo hydramnios at an estimated gestational age EGA of 29 weeks 3 days. Her blood group is O Rhesus D positive, and Genotype HbAA. No known premorbid illness. Her last confinement was of a male child delivered via CS and died within 12 hours of birth.</p> <p>This reported case of suspected FNAIT was a baby received alive after CS with birthweight of 1,060g and APGAR score of 7<sup>1</sup>8<sup>5</sup> transiently, and was noticed to be bleeding from the mouth and anus shortly after birth. Thereafter, he had thrombocytopenia, persistent anaemia, several apneic attacks, seizures, desaturation and died after 42 hours of life despite all prompt clinical interventions. Autopsy summary includes anaemia, central cyanosis, petechial hemorrhage, diffuse alveolar damage, cerebral edema, acute tubular necrosis, small for gestational age and placental vasculopathy.</p> <p><strong>Conclusion: </strong>Fetal and neonatal alloimmune thrombocytopenia is a rare disorder and yet poses a challenging diagnosis and treatment plan in resource-limited centres especially in developing countries. Although the clinical findings of the reported suspected case were not classical as previously reported by other studies, they’re pointers to our curiosity and open to further criticism.</p> Odunayo Afolayan Samson Ojedokun Oluwakayode Ashaolu Esther Kosoko Temitope Oyelami Michael Onigbinde Copyright (c) 2024 Author(s). The licensee is the journal publisher. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. 2024-11-05 2024-11-05 18 24 10.56557/jocrims/2024/v10i18930