PREDICTORS OF MORTALITY AND OUTCOMES FOR HOSPITALIZED PATIENTS WITH MIDDLE EAST RESPIRATORY SYNDROME CORONA VIRUS INFECTION
M. ABD-ELGAWAD
Department of Chest, Faculty of Medicine, Zagazig University, Egypt and Department of Chest, King Fahd Hospital, Almadinah Almunawwarah, Kingdom of Saudi Arabia
M. MOSAAD *
College of Medicine, Taibah University, Almadinah Almunawwarah, Kingdom of Saudi Arabia and Department of Endemic and Infectious Diseases, Faculty of Medicine, Suez Canal University, Egypt
TAREK AMEEN
Department of Internal Medicine, King Fahd Hospital, Almadinah Almunawwarah, Kingdom of Saudi Arabia and Department of Internal Medicine, Faculty of Medicine, Mansoura University, Egypt
A. FAISAL
Department of Endemic and Infectious Diseases, Faculty of Medicine, Suez Canal University, Egypt
*Author to whom correspondence should be addressed.
Abstract
Objectives: This work was done to investigate the predictors of mortality in non-survivors due to MERS- corona virus infection.
Methods: This study was conducted on 45 patients with corona virus infection who were admitted in king Fahd hospital, Almadinah Almunawwarah, Kingdom of Saudi Arabia during the period from October 2013 to June 2014. The studied patients were subjected to thorough medical history, clinical exam, complete laboratory investigations and nasal swabs and/or endotracheal secretion swabs for the intubated patients for detection of corona virus by polymerase chain reaction (rRT-PCR). Treatment was carried out according to WHO guidelines and the outcomes were recorded by comparing the survivors with the non-survivors.
Results: This study showed that most of the non- survivors were smokers, and presented with dyspnoea (88.9%), cough (83.3%), fever (94.4%) and bilateral radiological pulmonary infiltrates (83.3%). Twenty seven patients (60%) out of the 45 studied patients, and 17 patients (94.5%) out of 18 non- survivors had at least one co-morbid condition. the duration of mechanical ventilation (MV), and the length of ICU and hospital stay were significantly prolonged in the non- survivors group compared to the survivors. There was statistically significant positive correlation between death and Duration of illness before hospitalization, smoking severity, presence of obesity, diabetes mellitus, end-stage renal diseases, and renal transplantations.
Conclusions: Advanced age, smoking severity, bilateral radiological pulmonary infiltrates, and presence of associated co-morbidities were risk predictors for mortality in hospitalized corona virus infected patients.
Keywords: MERS Corona virus, outcome, mortality