Investigating the Relationship of Acute Cardiac Effects of Daphnia magna with Chemical Properties of Marine Pollutants


Published: 2023-09-19

DOI: 10.56557/jogee/2023/v18i48391

Page: 49-64

Jinwoo Lee *

Marine Biology Divisions, STEM Science Center, 111 Charlotte Place, Englewood Cliffs, NJ 07632, United States.

*Author to whom correspondence should be addressed.


Pollutant inflow from the inland water body is one of the most significant factors affecting marine ecosystems' health status. Common artificial pollutants that arrive at the sea include herbicides, pesticides, detergents, fertilizers, oil, industrial chemicals, and sewage. These chemicals can adversely affect marine organisms. Even though Daphnia mostly lives in freshwater, Daphnia magna is universally thriving worldwide. So, the cardiac effects on Daphnia by the pollutants were deemed to be thoroughly examined for estimating the impact of the chemicals on marine organisms. In this study, Daphnia was exposed to the serially diluted solutions of the ten most inland-spreading pollutants for 30 minutes, and the heartbeat changes after the incubation was measured in bpm. And the change percentages from the incubation were compared with the chemical properties to investigate their relationship. The result showed that the xlogP, rotatable bond count, and heavy atom count were somewhat correlated with the leading coefficients of polynomial functions derived from the heartbeat change graphs. Meanwhile, molecular weight, topological PSA, and complexity were more poorly related. The findings might contribute to developing new chemicals for using on-land environmental management eventually to conserve marine ecology.

Keywords: Acute cardiac effects, chemical properties, daphnia magna, herbicides, insecticides, marine biology, pollution

How to Cite

Lee , J. (2023). Investigating the Relationship of Acute Cardiac Effects of Daphnia magna with Chemical Properties of Marine Pollutants . Journal of Global Ecology and Environment, 18(4), 49–64.


Download data is not yet available.


Ward ND, Megonigal JP, Bond-Lamberty B, et al. Representing the function and sensitivity of coastal interfaces in Earth system models, Nature Communication. 2020;11:2458.


Maha Ahmed Mohamed Abdallah. Endocrine disruptors as pollutants in marine ecosystem: A case study in Egypt, The Open Biotechnology Journal. 2016;10(Suppl-1, M11):131-150.

Evanthia DK, Jean-Pieere B, Linda CG, Russ H, Gail SP, Ana MS, et al. Endocrine-disrupting chemicals: An endocrine society scientific statement, Endocrine Reviews. 2009;30(4):293- 342.

Eve L, Fervers B, Le Romancer M, Etienne-Selloum N. Exposure to Endocrine Disrupting Chemicals and Risk of Breast Cancer, International Journal of Molecular Sciences. 2020;21(23):9139.

Windsor FM, Ormerod SJ, Tyler CR. Endocrine disruption in aquatic systems: Up-scaling research to address ecological consequences, Biological Reviews Camb Philos Soc. 2018;93(1):626-641.

Štefanac T, Grgas D, Landeka Dragičević T. Xenobiotics-Division and Methods of Detection: A Review, Journal of Xenobiotoxicology. 2021;11(4):130-141.

Kavlock RJ, Daston GP, De Rosa C, Fenner-Crisp P, Gray LE, Kaattari S, et al, Research needs for the risk assessment of health and environmental effects of endocrine disruptors: A report of the U.S. EPA-sponsored workshop; 1 August 1996.

Acerini CL. Endocrine disrupting chemicals: A new and emerging public health problem?, Archives of Disease in Childhood. 2006;91(8):633-641.

Hyun-Shik Chang, Kwang-Ho Choo, Byungwhan Lee, Sang-June Choi. The methods of identification, analysis, and removal of endocrine disrupting compounds (EDCs) in water, Journal of Hazardous Materials. 2009;172(1):1-12.

Ze-hua Liu, Yoshinori Kanjo, Satoshi Mizutani. Removal mechanisms for endocrine disrupting compounds (EDCs) in wastewater treatment — physical means, biodegradation, and chemical advanced oxidation: A review, Science of The Total Environment. 2009;407(2):731-748.

Chris G Campbell, Sharon E Borglin, F Bailey Green, Allen Grayson, Eleanor Wozei, William T Stringfellow. Biologically directed environmental monitoring, fate, and transport of estrogenic endocrine disrupting compounds in water: A review, Chemosphere. 2006;65(8):1265-1280.

Metcalfe CD, Bayen S, Desrosiers M, Muñoz G, Sauvé S, Yargeau V. An introduction to the sources, fate, occurrence and effects of endocrine disrupting chemicals released into the environment, Environmental Research. 2022;207:112658.

Lee HB, Peart TE, Gris G, Chan J. Endocrine-Disrupting Chemicals in Industrial Wastewater Samples in Toronto, Ontario, Water Quality Research Journal. 2002;37(2):459–472.

Abdallah MAM. Endocrine disruptors as pollutants in marine ecosystem: A case study in Egypt, The Open Biotechnology Journal. 2016;10(Suppl-1, M11):131- 150.

Carol F Kwiatkowski, David Q Andrews, Linda S Birnbaum, Thomas AB, et al. Scientific basis for managing PFAS as a chemical class, Environmental Science & Technology Letters. 2020;7(8):532- 543.

Dodson SI, Hanazato T. Commentary on Effects of Anthropogenic and Natural Organic Chemicals on Development, Swimming Behavior, and Reproduction of Daphnia, a Key Member of Aquatic Ecosystems. Environmental Health Perspectives. 1995;103(suppl 4):7–11.

Sarnelle, Orlando. Daphnia as Keystone Predators: Effects on Phytoplankton Diversity and Grazing Resistance. Journal of Plankton Research. 2005;27(12):1229–1238.

Chislock MF, Doster E, Zitomer RA, Wilson AE. Eutrophication: Causes, consequences, and controls in aquatic ecosystems. Nature Education Knowledge. 2013;4(4):10.

Abraham MH, Chadha HS, Leitao RAE, Mitchell RC, Lambert WJ, Kaliszan R, et al. “Determination of solute lipophilicity, as log P(octanol) and log P(alkane) using poly(styrene–divinylbenzene) and immobilised artificial membrane stationary phases in reversed-phase high-performance liquid chromatography. Journal of Chromatography A. 1997;766(1-2):35–47.

Lozowicka B, Kaczynski P, Nawrot J. Study of lipophilicity of alpha-asarone derivatives and their deterrent activity against the Colorado potato beetle, Cent. Eur. Journal of Chemistry. 2013;11(12):2120-2133.

Prasanna S, Doerksen RJ. Topological polar surface area: A useful descriptor in 2D-QSAR, Current Medicinal Chemistry. 2009;16(1):21-4.

Shityakov S, Neuhaus W, Dandekar T, Förster C. Analysing molecular polar surface descriptors to predict blood-brain barrier permeation. International Journal of Computational Biology and Drug Design. 2013;6(1-2):146-156.

Ertl P, Rohde B, Selzer P. Fast calculation of molecular polar surface area as a sum of fragment-based contributions and its application to the prediction of drug transport properties. Journal of Medicinal Chemistry. 2000;43(20):3714-3717.

Lu JJ, Crimin K, Goodwin JT, Crivori P, Orrenius C, Xing L, Burton PS, et al, Influence of molecular flexibility and polar surface area metrics on oral bioavailability in the rat. Journal of Medicinal Chemistry. 2004;47(24):6104-6107.

Fang-Yu Lin, Alexander D MacKerell Jr. Do Halogen–hydrogen bond donor interactions dominate the favorable contribution of halogens to ligand–protein binding? The Journal of Physical Chemistry B. 2017;121(28):6813-6821.

Leach AR, Hann MM. Molecular complexity and fragment-based drug discovery: Ten years on. Current Opinion in Chemical Biology. 2011;15(4):489- 496.

Moon SJ, Kim M, Kim E, Lee J, Song JM. Heartbeat and Vertical Migration Effects of Magna Daphnia by Environmental Hormones. International Journal of Applied Environmental Sciences. 2016;11(4):941-56.

Fernandez-Cornejo J, Nehring R, Osteen C, Wechsler S, Martin A, Vialou A. Pesticide use in U.S. agriculture: 21 selected crops, 1960-2008, United States Department of Agriculture, Economic Information Bulletin No. 124; 2014.

National Pesticide Information Center, 2,4-D Technical Fact Sheet.


NIH, Sodium Laureth Sulfate, National Library of Medicine, National Center for Biotechnology Information.


Etang J, Pennetier C, Piameu M, Bouraima A, Chandre F, Awono-Ambene P, et al. When intensity of deltamethrin resistance in Anopheles gambiae sl leads to loss of Long Lasting Insecticidal Nets bio-efficacy: A case study in north Cameroon. Parasites & Vectors. 2016;9(1):1-10.

Webber CL, Shrefler JW, Brandenberger LP, Taylor MJ, Carrier LK, Shannon DK. Weed Control Efficacy With Ammonium Nonanoate for Organic Vegetable Production. International Journal of Vegetable Science. 2010;17(1):37– 44.

Mount GA, Lofgren CS, Pierce NW, Husman, CN. Ultra-low volume nonthermal aerosols of malathion and naled for adult mosquito control. Mosquito News. 1968;28(1):99-103.

Duke SO, Powles SB. Glyphosate: A once-in-a-century herbicide. Pest Management Science. 2008;64(4):319–325.

Chen W, Viljoen AM. Geraniol—a review of a commercially important fragrance material. South African Journal of Botany. 2010;76(4): 643-651.

Hougard JM, Duchon S, Zaim M, Guillet P. Bifenthrin: A useful pyrethroid insecticide for treatment of mosquito nets. Journal of Medical Entomology. 2002;39(3):526-533.

Singh S, Kumar V, Chauhan A, Datta S, Wani AB, Singh N, Singh J. Toxicity, degradation and analysis of the herbicide atrazine. Environmental Chemistry Letters. 2017;16(1):211- 237.