RESULTS OF A COMPARATIVE STUDY OF ANTI-INFLAMMATORY EFFECT OF VITASTEROIDS WITH A PREPARATION OF GLUCOCORTICOSTEROID SERIES – PREDISOLONE
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Published:
Feb 12, 2021
Page:
54-60
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SYROV VLADIMIR NIKOLAYEVICH
Institute of Plant Chemistry Named after Academician S. Yu. Yunusov Academy of Sciences of the Republic of Uzbekistan, Tashkent, Uzbekistan.
KHUSHBAKTOVA ZAYNAB ABDURAKHMANOVNA
Institute of Plant Chemistry Named after Academician S. Yu. Yunusov Academy of Sciences of the Republic of Uzbekistan, Tashkent, Uzbekistan.
BOBAYEV ISAMIDDIN DAVRONOVICH
Institute of Plant Chemistry Named after Academician S. Yu. Yunusov Academy of Sciences of the Republic of Uzbekistan, Tashkent, Uzbekistan.
SHAKHMUROVA GULNARA ABDULLAEYVNA
Tashkent State Pedagogical University Named After Nizami, Tashkent, Uzbekistan.
Abstract
Vitasteroids: ixocarpalactone A, isolated from the leaves of Physalis ixocarpa Brot., and 24.25 - epoxyvitanolide D, isolated from the leaves of Physalis angulata L., exhibit a pronounced antiphlogistic effect in experiments on normal experimental animals, inhibiting both exudative and proliferative phases of inflammation. It was defined, caused by the introduction of complete Freund’s adjuvant to animals, and their clear anti-inflammatory effect is combined with an improvement of general biological and immunological indicators of the state of the organism in experiments on rats with chronic adjuvant arthritis. Which we mean a reliable tendency to normalize the content of leukocytes and erythrocytes, erythrocyte sedimentation rate, fibrinogen, blood clotting time, as well as the content of circulating immune complexes in the blood. In terms of their activity in both cases of the conducted experiments, the studied vitasteroids were not inferior to the well-known preparation of the glucocorticosteroid series - prednisolone
Keywords:
Vitasteroids, ixocarpalactone A, 24, 25 - epoxyvitanolide D, inflammatory process, adjuvant arthritis, anti-inflammatory and immunomodulatory effects.
Article Details
How to Cite
NIKOLAYEVICH, S. V., ABDURAKHMANOVNA, K. Z., DAVRONOVICH, B. I., & ABDULLAEYVNA, S. G. (2021). RESULTS OF A COMPARATIVE STUDY OF ANTI-INFLAMMATORY EFFECT OF VITASTEROIDS WITH A PREPARATION OF GLUCOCORTICOSTEROID SERIES – PREDISOLONE. Journal of Medicine and Health Research, 5(1), 54-60. Retrieved from https://ikprress.org/index.php/JOMAHR/article/view/5924
Section
Original Research Article
References
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Khakimov ZZ, Rakhmanov AKh, Bekova NB. Experimental study of the effect of cynarizine on the course of the exudation process. Infection, Immunity and Pharmacology. 2020;1:108-114.
Vengerovsky AI, Burkova VN, Yudina NV, Yatsenkov AI. Anti-inflammatory and analgesic effect of polar lipids in antlers of maral and peat in experimental inflammation. Bulletin of Siberian Medicine. 2012;6:31-36.
Syrov VN, Kravets SD, Khushbaktova ZA, Nabiev AN, Vollerner YuS, Horowitz MB. Research on steroid genins and glycosides as anti-inflammatory agents. Chemistry Pharmaceutics Journal. 1992;5:71-76.
Aminov SD, Vakhabov AA, Nabiev AN. Pharmacological properties of coumarins and flavonoids isolated from whole leaf (Haplophyllum obtusifolium), yantak (Alhagi pseudalhagi) and licorice (Glycyrrhiza glabra). Tashkent. 2016;120.
Syrov VN, Islamova JI, Polyarush SV, Narbutaeva DA, Khushbaktova ZA. On anti-inflammatory and antimicrobial activity of polymeric proanthocyanidins. Practical Phytotherapy. 2015;2:5-12.
Syrov NV, Tursunova NV, Khushbaktova ZA, Mukhamatkhanova RF. On the anti-inflammatory activity of the sum of lactones from Artemisia leucodes. Reports of the Academy of Sciences of the Republic of Uzbekistan. 2007;4:68-70.
Syrov VN, Islamova ZhI, Vasina OE, Bobaev ID, Khushbaktova ZA. Angunalidi 4-oxoangunolide as effective anti-inflammatory preparations. Bulletin of the Tashkent Medical Academy. 2018;1:49-51.
Makhmudova MM, Saidkhodzhaeva DM, Bobaev ID, Syrov VN, Abdullaev ND. Anti-inflammatory activity of Datura stramonium vitasteroids. Infection, Immunity and Pharmacology. 2019;1:100-106.
Budhiraja RD, Pawan Krishan, Sudhir S. Biological activity of withanolides. Journal of Scientific and Industrial Research. 2000;59:904–911.
Mashkovsky MD. Medicines. Moscow: RIA New Wave. 2008;569–570.
Abdullaev ND, Vasina OE, Maslennikova VA, Abubakirov NK. Vitasteroids hysalis VI. Study of 1H and 13C spectra of vitasteroids ixocarpalactone A and ixocarpanolide. Chemistry of Natural Compounds. 1986;3:326-332.
Vasina OE, Maslennikova VA, Abdullaev ND, Abubakirov NK. Vitasteroids Physalis VII. 14α - oxyixocarpanolide and 24.25 - epoxyvitanolide D. Chemistry of Natural Compounds. 1986;5:596-602.
Khabriev RU. Guidelines for experimental (preclinical) study of new pharmacological substances. Moscow: Publishing House “Medicine. 2005;832.
Sabirova FM, Madaminov AA. On the anti-inflammatory activity of a new water-soluble derivative of gossypol mebavin. Experimental and Clinical Pharmacology. 2003;6:48- 49.
Kamyshnikov VS. Reference book on clinical and biochemical research and laboratory diagnostics. Moscow: MED press – inform; 2009.
European Convention for the Protection of Vertebrate Animals used for Experimental or Other Scientific Purposes” // Strasbourg, March 18, 1986). The text of the document is checked against official website of the Council of Europe; 1986.
Available:http: //conventions.coe.int, as of 31.08.2005
Sakhibov AD, Syrov VN, Usmanova AS, Khushbaktova ZA, Vasina OE, Abubakirov NK. On the immunosuppressive properties of vitasteroids in experiment. Reports of the Academy of Sciences of the Uzbek SSR. 1990;1:43-45.