Correlation between Blood G6PD Status and ABO Setup in Developing Significant Neonatal Hyperbilirubinemia
Odunayo Afolayan
Department of Pediatrics and Child Health, LAUTECH Teaching Hospital, Ogbomoso, Oyo State, Nigeria.
Michael Onigbinde *
Department of Pediatrics and Child Health, LAUTECH Teaching Hospital, Ogbomoso, Oyo State, Nigeria.
Temitope Oyelami
Department of Pediatrics and Child Health, LAUTECH Teaching Hospital, Ogbomoso, Oyo State, Nigeria.
Ifedola Oredola
Department of Chemical Pathology, LAUTECH Teaching Hospital, Ogbomoso, Oyo State, Nigeria.
Samson Ojedokun
Department of Chemical Pathology, LAUTECH Teaching Hospital, Ogbomoso, Oyo State, Nigeria.
*Author to whom correspondence should be addressed.
Abstract
Background: Blood group incompatibility and G6PD deficiency are significant risk factors for developing neonatal hyperbilirubinemia. This study aimed to find the association between ABO incompatibility and G6PD deficiency in predicting the development of significant hyperbilirubinemia among term neonates in Ogbomoso, Nigeria.
Methods: The study was a hospital-based longitudinal cross-sectional study among 471 term neonates conducted in selected health facilities in Ogbomoso over a period of 9 months. General clinical assessment was done. Initial blood specimens were obtained via the umbilical cord for bilirubin test at birth. Then follow up specimen after 72hrs for Bilirubin estimation, blood group and G6PD assays. The data were analyzed using SPSS version 23.0.
Results: The mean value of cord bilirubin was 1.73 ± 0.85 and follow-up level of 5.79 ± 3.16. Of four hundred and seventy-one term neonates were recruited, 20 had significant Hyperbilirubinemia at follow-up with a p-value of 0.966 and 0.702 respectively, which is not statistically significant. Hyperbilirubinemia (≥ 12mg/dl) is prevalent in 4.2%. Ninety-six (20.3%) had ABO incompatibility among which 4(4.2%) had hyperbilirubinemia. Also, a prevalence of 23.5% for G6PD deficiency of which 3.6% have hyperbilirubinemia. There was no association between ABO Setup, G6PD Status, and development of significant Neonatal.
Conclusion: This study does not demonstrate association between ABO incompatibility setup; G6PD deficiency status and development of significant neonatal hyperbilirubinaemia between seventy two hours and ninety two postnatal follow up.
Keywords: Hyperbilirubinemia, blood ABO, G6PD deficiency