PEEL OF Citrus reticulata DERIVED PHYTOCHEMICALS AGAINST GLYCERALDEHYDES- 3 – PHOSPHATE OF ENTAMOEBA HISTOLYTICA
BIREN PATTANAIK
School of Applied Sciences, Centurion University of Technology and Management, Odisha, India.
BIBHUPRASAD MISHRA
School of Applied Sciences, Centurion University of Technology and Management, Odisha, India.
MANORANJAN BEHERA
School of Applied Sciences, Centurion University of Technology and Management, Odisha, India.
SITARAM SWAIN
School of Applied Sciences, Centurion University of Technology and Management, Odisha, India.
GAGAN KUMAR PANIGRAHI
School of Applied Sciences, Centurion University of Technology and Management, Odisha, India.
DIPANKAR BHATTACHARYAY *
School of Applied Sciences, Centurion University of Technology and Management, Odisha, India.
*Author to whom correspondence should be addressed.
Abstract
The phytochemicals or secondary metabolites from extract of Citrus reticulata may cure dysentery, primarily which is caused by Entamoeba hystolytica. To restrict the activity of Entamoeba hystolytica, several bio molecules can be deployed, of which the phytochemicals can be the best alternative. Molecular docking-based screening of a few phytochemicals revealed that few of phytochemicals effectively associate with the active site of the Glyceraldehydes- 3 – Phosphate and hence bears diagnostic and therapeutic potentials against Entamoeba hystolytica causing dysentry. “High positive values of -CDOCKER energy and -CDOCKER interaction energy” indicated that the Anthranalic acid may effectively inhibit the glyceraldehydes-3-phosphate dehydrogenase enzyme thereby interrupting the life cycle of the organism.
Keywords: Phytochemical, biovia, discovery studio, Citrus reticulate, Entamoeba histolytica.