Moringa oleifera DERIVED PHYTOCHEMICALS AGAINST MALARIA: AN In silico ANALYSIS

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Published: 2020-06-22

Page: 162-165


SEEMA SUVA DARSHINI

Centurion University of Technology and Management, Odisha, India.

SONALI SUCHISMITA BEHERA

Centurion University of Technology and Management, Odisha, India.

BHABATOSH SWAIN

Centurion University of Technology and Management, Odisha, India.

MUKUNDJEE PANDEY

Centurion University of Technology and Management, Odisha, India.

GAGAN KUMAR PANIGRAHI

Centurion University of Technology and Management, Odisha, India.

DIPANKAR BHATTACHARYAY

Centurion University of Technology and Management, Odisha, India.

*Author to whom correspondence should be addressed.


Abstract

Phytochemicals are plant derived biomolecules which are believed to protect cells from damage. It has been reported that Moringa oleifera L. (Moringaceae) is n economically important plant, distributed across tropics and subtropics whose extract is used to cure malaria. The plant extract contains different phytochemicals. Malaria is caused by Protozoan Parasite Plasmodium. L-Lactate dehydrogenase is one of its vital enzymes. In silico approach using Biovia’s Discovery Studio was used to see the molecular docking between phytochemicals derived from Moringa oleifera L. and the enzyme of interest. -CDOCKER energy and –CDOCKER interaction energy represents the strength of the interaction. Particularly, the phytochemicals hexadecanoic acid and anthraquinone can effectively deactivate the L-Lactate dehydrogenase enzyme and thus can interfere with the life cycle of Plasmodium.

Keywords: Phytochemical, biovia, discovery studio, Moringa oleifera, Plasmodium


How to Cite

DARSHINI, S. S., BEHERA, S. S., SWAIN, B., PANDEY, M., PANIGRAHI, G. K., & BHATTACHARYAY, D. (2020). Moringa oleifera DERIVED PHYTOCHEMICALS AGAINST MALARIA: AN In silico ANALYSIS. PLANT CELL BIOTECHNOLOGY AND MOLECULAR BIOLOGY, 21(13-14), 162–165. Retrieved from https://ikprress.org/index.php/PCBMB/article/view/5170

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