A SYSTEMATIC REVIEW ON EXTRACTION METHODS, PHARMACOLOGY, PHARMACOKINETICS AND CLINICAL STUDIES OF BIOACTIVE LEAD: 6-GINGEROL
SHARMA NAVNI
Department of Pharmacy (UIPS), Chandigarh University, Gharuan, Mohali, Punjab 140113, India.
KUMAR ARORA
Department of Pharmacy (UIPS), Chandigarh University, Gharuan, Mohali, Punjab 140113, India.
PATEL ANIKET
Department of Pharmacy (UIPS), Chandigarh University, Gharuan, Mohali, Punjab 140113, India.
*Author to whom correspondence should be addressed.
Abstract
A comparative study has been made between the extraction procedures of {6}-Gingerol based on the instruments, solvents, extraction time and extraction temperature. {6}-Gingerol is the biochemically and therapeutically active amongst various constituents possessed by ginger. The extraction of {6}-Gingerol to obtain high purity compound expresses a challenging and significant task in the pharmaceutical industry because it act as lead compound having anti-tumor activity. Various extraction processes are being used to acquire active constituent from Ginger. A growing body of research suggested that 6-Gingerol has an anti-cancer, anti-inflammatory, analgesic, anti-mutagenic and anti-cholesterol target also. It concluded that pressurized liquid extraction procedure is the best which provide high yield as compared to other extraction processes.
Keywords: Introduction, history, extraction processes, pharmacology, pharmacokinetics clinical affects.