PLANT-DERIVED ANTIMICROBIALS (PDAms) TO CONTROL URINARY TRACT INFECTIONS
ANU KUMAR *
University Institute of Biotechnology, Chandigarh University, Gharuan, Mohali, Punjab, India and University Institute of Pharmacy, India.
RITA SINGH MAJUMDAR
School of Engineering and Technology, Sharda University, Greater Noida, UP, India and University Institute of Pharmacy, India.
*Author to whom correspondence should be addressed.
Abstract
Urinary Tract Infection has been recognized second most common infection after respiratory infection and is most frequent in women, accounting for nearly 60% of overall UTIs. Caused by single bacterial species E. coli, which is the most frequently infecting organisms. We undertook this study to know the prevalence of MDR E. coli among various urine samples and to find out antibacterial activity of different herbal extracts against these resistance strains. Out of 40 samples 9 isolates of E .coli (22%) were recovered, which were considered for study. Among these 9 E. coli isolates, 2 (28.6%) were found multiple drug resistant (MDR). The isolates showed high levels of resistance to Amoxycilin (AMX25), Oxacilin (OX1), Ceftazidime (CAZ30) and Ceftriaxone (CTR30). Nine plant species were screened for anti MDR activity and out of 9 plants the maximum zone of inhibition was observed in the aqueous extract of Terminalia chebula (22 mm) & Callistemon (22 mm)] which were found more potent than the previous studies. In conclusion, the prevalence of MDR Producers at our study was lower in comparison to the prevalence reported from other studies. The high rate of resistance in bacteria for antibiotics need alternative drug line to control UTI.
Keywords: Antimicrobial resistance, Escherichia coli, MDR, UTI