In silico ANALYSIS OF EFFECT OF PHYTOCHEMICALS FROM Paprika oleoresin (Capsicum annum L.) AGAINST DIAMINOPIMELATE DEHYDROGENASE OF Clostridium tetani CAUSING TETANUS
NABAKRUSHNA BEHERA
Centurion University of Technology and Management, Odisha, India.
ASHOK KUMAR SAHOO
Centurion University of Technology and Management, Odisha, India.
GAGAN KUMAR PANIGRAHI
Centurion University of Technology and Management, Odisha, India.
SARTHAK SIDDHANT MISHRA
Centurion University of Technology and Management, Odisha, India.
SASMITA PATRA
Centurion University of Technology and Management, Odisha, India.
K. V. D. PRAKASH
Centurion University of Technology and Management, Odisha, India.
DIPANKAR BHATTACHARYAY
Go to Market Laboratory, Gram Tarang, Odisha, India and Centurion University of Technology and Management, Odisha, India.
*Author to whom correspondence should be addressed.
Abstract
Clostridium tetani causes tetanus. Strikingly, tetanus rises primarily during specific molecular events, thus acting as a potential clinical biomarker. Further, tetanus may also activate further downstream events, supporting the detrimental phase. To restrict the activity of tetanus, several bio molecules can be deployed, of which the phytochemicals can be the best alternative. Molecular docking-based screening of a few phytochemicals revealed that the phytochemicals effectively associate with the active site of the protein and hence bears diagnostic and therapeutic potentials against tetanus.
Keywords: Phytochemical, biovia, discovery studio, Paprika oleoresin, Clostridium tetani.