ANTIMICROBIAL AND ANTIOXIDANT ACTIVITY OF Phyllanthus niruri MEDIATED SILVER NANOPARTICLES
R. PON PREEJA
Saveetha Dental College and Hospitals, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai, Tamil Nadu, India.
LAKSHMINARAYANAN ARIVARASU
Department of Pharmacology, Saveetha Dental College and Hospitals, Saveetha Institute of Medical and Technical Sciences (SIMATS), Saveetha University, Chennai-77, Tamil Nadu, India.
S. RAJESHKUMAR
Department of Pharmacology, Saveetha Dental College and Hospitals, Saveetha Institute of Medical and Technical Sciences (SIMATS), Saveetha University, Chennai-77, Tamil Nadu, India.
*Author to whom correspondence should be addressed.
Abstract
Aim: The aim of study is to evaluate the characterization and anti-fungal property of Phyllanthus niruri mediated silver nanoparticle
Introduction: Phyllanthus niruri is a tropical plant discovered in coastal areas also called as gale of the wind, stonebreaker or seed-under-leaf. The plant is of therapeutic significance for various illness like, influenza, vaginal inflammation, cancer, diabetes mellitus, diuretics, icterus, nephrolithiasis, indigestion. Green synthesis of nanoparticles denotes an improvement over other techniques because it is manageable, profitable, and fairly reproducible, and often results in more stable materials.Nanotechnology produced substances of various types at nanoscale level. ZnO NPs can proceed as smart weapons against multiple drug-resistant microorganisms and as an alternative for antibiotics.
Materials and Methods: Preparation of Phyllanthus niruri mediated silver nanoparticles was followed by antioxidant activity evaluated by DPPH activity and antimicrobial activity.
Results: The study shows that Phyllanthus niruri have great potential as a natural antioxidant and antimicrobial source. DPPH radical-scavenging activity of all the extracts of Ph. niruri revealed very high potency. The standard solution used showed 85% of inhibition.
Conclusion: The antibacterial and antifungal effect of Phyllanthus niruri mediated AgNP which were evaluated against the pathogen lactobacillus, S. mutans, C. albicans showed a significant activity. Anti oxidant activity by inhibition of the DPPH radical in vitro showed that the Phyllanthus niruri AgNP was equally potent compared to Standard Ascorbic acid. DPPH radical-scavenging activity of all the extracts of Ph. niruri revealed very high potency. The standard solution used showed 85% of inhibition to the acid radical.ZnO NPs can proceed as smart weapons against multiple drug-resistant microorganisms and as an alternative for antibiotics.
Keywords: Candida albicans, DPPH, green synthesis, Phyllanthus niruri, silver nanoparticle