ANTIMICROBIAL ACTIVITY OF CLOVE AND CINNAMON FORMULATION MEDIATED SELENIUM NANOPARTICLES AGAINST ORAL PATHOGENS
KEERTHIGA NAGARAJAN
Saveetha Dental College and Hospitals, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai -77, India.
ARVINA RAJASEKAR
Department of Periodontics, Saveetha Dental College and Hospitals, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai -77, India.
S. RAJESHKUMAR
Department of Pharmacology, Saveetha Dental College and Hospitals, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai -77, India.
*Author to whom correspondence should be addressed.
Abstract
Background: The introduction of nanoparticles (NPs) has modernized a wide spectrum of fields including medicine in particular. Nanoparticles have revolutionized targeted drug delivery by minimizing the toxicity and side effects that commercially available drugs may have on patients. Clove and cinnamon have long been used in traditional medicine for the treatment of a wide variety of ailments and diseases. Due to its simplicity and eco-friendliness, the green synthesis of nanoparticles has been gaining importance.
Aim: This study was aimed to synthesize clove and cinnamon formulation mediated selenium nanoparticles and assess their antimicrobial activity against oral pathogens.
Materials and Methods: Clove and cinnamon formulation mediated selenium nanoparticles were synthesised in-vitro. The antimicrobial activity of SeNPs was evaluated against Streptococcus mutans and Lactobacillus using Kirby Bauer disc diffusion method.
Results: The clove-cinnamon extract mediated SeNPs showed effective antimicrobial activity comparable to that of commercially available drugs.
Conclusion: It can thus be concluded that clove-cinnamon mediated selenium nanoparticles have the ability to be used as an effective antibiotic. This formulation needs to be further purified to isolate the component in the extract that makes it effective to be used in large scale production for targeted drug delivery against a wide array of oral microbial infections.
Keywords: Antimicrobial activity, clove, cinnamon, green synthesis, nanoparticles, oral pathogens, selenium