CYTOTOXICITY OF COPPER NANOPARTICLES SYNTHESIZED USING DRIED GINGER

Main Article Content

V. RIESHY
M. JEEVITHA
S. RAJESHKUMAR

Abstract

Copper nanoparticles find a variety of applications in almost every developing sector like medicine, agriculture and engineering, etc. This biotechnology combines the biological principles of both physical and chemical properties and produces nano-sized particles that have peculiar functions. Cytotoxicity is the quality of being toxic to cells. The present study aimed to analyse the cytotoxicity of copper nanoparticles that are biosynthesized using dried ginger. Copper nanoparticles were synthesized by green approach using dried ginger and were characterized by UV- Vis spectroscopy. The dried ginger mediated copper nanoparticles were subjected to cytotoxic tests for different concentrations by brine shrimp lethality assay. The results indicated that the copper nanoparticles synthesized from dried ginger showed reduced toxicity at lower concentrations. Thus, various nano-formulations of dried ginger mediated copper nanoparticles can be developed at optimal concentrations for therapeutics that are safe and economical.

Keywords:
Copper nanoparticles, cytotoxicity, brine shrimp lethality assay, dried ginger, green synthesis.

Article Details

How to Cite
RIESHY, V., JEEVITHA, M., & RAJESHKUMAR, S. (2020). CYTOTOXICITY OF COPPER NANOPARTICLES SYNTHESIZED USING DRIED GINGER. PLANT CELL BIOTECHNOLOGY AND MOLECULAR BIOLOGY, 21(55-56), 1-6. Retrieved from https://ikprress.org/index.php/PCBMB/article/view/5584
Section
Original Research Article

References

Agarwal H, Kumar SV, Rajeshkumar S. A review on green synthesis of zinc oxide nanoparticles: An eco-friendly approach. Resour Effic Technol. 2017;3(4):406-413.

Santhoshkumar J, Venkat Kumar S, Rajeshkumar S. Phyto-assisted synthesis, characterization and applications of gold nanoparticles – A review. Biochemistry and Biophysics Reports. 2017;11:46–57. DOI:http://dx.doi.org/10.1016/j.bbrep.2017.06.004

Menon S, Rajeshkumar S, Kumar V. A review on biogenic synthesis of gold nanoparticles, characterization and its applications. Resource-Efficient Technologies. 2017;3(4):516-527. DOI:https://doi.org/10.1016/j.reffit.2017.08.002

Rajeshkumar S, Poonam Naik. Synthesis and biomedical applications of cerium oxide nanoparticles–a review. Biotechnology Reports. 2018;17:1-5. DOI:https://doi.org/10.1016/j.btre.2017.11.008

Agarwal H, et al. Mechanistic study on antibacterial action of zinc oxide nanoparticles synthesized using green route. Chemico-Biological Interactions. 2018;60–70. DOI: 10.1016/j.cbi.2018.03.008

Menon, Soumya, Shrudhi Devi KS, Santhiya R, Rajeshkumar S, Venkat Kumar. Selenium nanoparticles: A potent chemotherapeutic agent and an elucidation of its mechanism. Colloids and Surfaces B: Biointerfaces. 2018;170:280-292. DOI:https://doi.org/10.1016/j.colsurfb.2018.06.006

Jeevitha M, Rajeshkumar S. Antimicrobial activity of silver nanoparticles synthesized using marine brown seaweed Spatoglossum asperum against oral pathogens. Indian Journal of Public Health Research & Development. 2019;10(11):3568-3573.

Rajeshkumar S. Green synthesis of different sized antimicrobial silver nanoparticles using different parts of plants-A review. International Journal of ChemTech Research. 2016;9(4):197–208.

Rajeshkumar S, et al. Anticariogenic activity of fresh Aloe vera gel mediated copper oxide nanoparticles. Indian Journal of Public Health Research & Development. 2019;3664. DOI: 10.5958/0976-5506.2019.04158.5

Meyer BN, Ferrigni NR, Putnam JE, Jacobsen LB, Nichols DJ, McLaughlin JL. Brine shrimp: A convenient general bioassay for active plant constituents. Planta Medica. 1982;45(05):31-4.

Sarah QS, Anny FC, Mir M. Brine shrimp lethality assay. Bangladesh Journal of Pharmacology. 2017;12(2):186-9.

Santhoshkumar J, et al. A biological synthesis of copper nanoparticles and its potential applications. Green Synthesis, Characterization and Applications of Nanoparticles. 2019;199–221. DOI: 10.1016/b978-0-08-102579-6.00009-5

Judith Vijaya J, et al. Bioreduction potentials of dried root of Zingiber officinale for a simple green synthesis of silver nanoparticles: Antibacterial studies. Journal of Photochemistry and Photobiology. B, Biology. 2017;177:62– 68.

Selvam K, et al. Biomimetic synthesis of copper nanoparticles using rhizome extract of Corallocarbus epigaeus and their bactericidal with photocatalytic activity. SN Applied Sciences; 2020. DOI: 10.1007/s42452-020-2811-3

Joseph AT, Prakash P, Narvi SS. Phytofabrication and characterization of copper nanoparticles using Allium sativum and its antibacterial activity. Int. J. of Sci., Eng. and Techn. 2016;4:463- 72.

Sakthivel AP. Microwave assisted synthesis and characterization of silver nanoparticles using Tridax procumbens and its anti-inflammatory activity against human blood cells. Journal of Nanomaterials & Molecular Nanotechnology; 2015. DOI: 10.4172/2324-8777.1000170

Nagore PB, et al. Green synthesis of luminescent copper oxide nanoparticles using ginger lily leaves extract. Journal of Inorganic and Organometallic Polymers and Materials; 2020. DOI: 10.1007/s10904-020-01614-6

El-Refai AA, et al. Cytotoxicity of aqueous garlic and ginger metal nanoparticles extracts against tumor cell lines “In vitro”. Journal of Food and Dairy Sciences. 2018;51–58. DOI: 10.21608/jfds.2018.35186

Chunyan W, Valiyaveettil S. Correlation of biocapping agents with cytotoxic effects of silver nanoparticles on human tumor cells. RSC Advances. 2013;14329. DOI: 10.1039/c3ra41346b

Renugadevi K, Kumar N, Valli Nachiyar C. Phytosynthesis of silver nanoparticle using ginger extract as a reducing agent by microwave irradiation method and in vitro evaluation of its antibacterial activity and cytotoxicity. Research Journal of Pharmacy and Technology. 2017;4142. DOI: 10.5958/0974-360x.2017.00754.5