Main Article Content
Curculigo orchioides plant is a perennial herb having tuberous fleshy roots, leaves and flowers. The plant bears tremendous medicinal properties with anti-cancer, immune-stimulant, anti-diabetic, aphrodisiac, and anti-oxidant activity. The plant extract can be used in diseases like asthma, jaundice, diarrhoea, colic, hemorrhoids, snake bite, edema, and debilitating condition. Comprehensive analysis of different species of Curculigo plant has shown the presence of about 110 phytochemicals with wide range of pharmacological properties. Curculigoside is an active component in the extract of plant and it has many isoforms. It shows anti-arthritic effect through regulation of the JAK/STAT/NF‑κB signaling pathway. The isoform A seems to have angiogenic function mediated through VCAM-1/Egr-3/CREB/VEGF signaling pathway. There is a polysaccharide called O-acetyl glucomannan found in Curculigo orchioides rhizome part, having prominent effect on proliferation and differentiation of mouse primary osteoblastic cells, which indicates the efficacy of this polysaccharide in treatment of osteoporosis. The B and D isoforms of curculigoside are having therapeutic effects against Alzheimer’s disease. Moreover, curculigoside is also effective for treatment of ulcerative colitis. The present review article describes the therapeutic properties of Curculigo orchioides plant against many diseases, and the potential of active principles present in the plant extract, which can be utilized in future for drug formulation against various diseases.
Francis SV, Senapati SK, Rout GR. Rapid clonal propagation of Curculigo orchioides Gaertn., an endangered medicinal plant". In Vitro Cellular & Developmental Biology - Plant. 2007;43(2):140.
Chauhan NS, Sharma V, Thakur M, Dixit VK. Curculigo orchioides: The black gold with numerous health benefits. Journal of Chinese Integrative Medicine. 2010;8(7): 613-23.
Jiang W, Fu F, Tian J, Zhu H, Hou J. Curculigoside A attenuates experimental cerebral ischemia injury in vitro and vivo. Neuroscience. 2011;192:572-579.
Zhu H, He J, Ye L, Lin F, Hou J, Zhong Y, Jiang W. Mechanisms of angiogenesis in a Curculigoside A-treated rat model of cerebral ischemia and reperfusion injury. Toxicol Appl Pharmacol. 2015;288(3):313-21.
Riviere C, Richard T, Vitrac X, Mérillon JM, Valls J, Monti JP. New polyphenols active on β-amyloid aggregation. Bioorganic & Medicinal Chemistry Letters. 2008;18(2):828-831.
Zhao L, Liu S, Wang Y, Zhang Q, Zhao W, Wang Z, et al. Effects of Curculigoside on memory impairment and bone loss via anti-oxidative character in APP/PS1 Mutated transgenic mice. PLoS ONE. 2015;10(7): e0133289.
Wang S, Liu W, Wang J, Bai X. Curculigoside inhibits ferroptosis in ulcerative colitis through the induction of GPX4. Life Sci. 2020;259:118356.
Xue L, Jiao L, Wang Y, Nie Y, Han T, Jiang Y, Rahman K, Zhang Q, Qin L. Effects and interaction of icariin, curculigoside, and berberine in er-xian decoction, a traditional chinese medicinal formula, on osteoclastic bone resorption. Evid Based Complement Alternat Med. 2012;490843.
Nie Y, Dong X, He Y, Yuan T, Han T, Rahman K, Qin L, Zhang Q. Medicinal plants of genus Curculigo: traditional uses and a phytochemical and ethnopharmaco-logical review. J Ethnopharmacol. 2013; 147(3):547-63.
Rao PS, Beri RM. Mucilage from the tubers of Curculigo orchioides. Proc. Indian Acad. Sci. 1951;34A:27-31.
Kubo M, Namba K, Nagatnoto N, Nagao T, Nakanishi J, Uuo H, Nishimura H. A new phenolic glycoside, curculigoside from rhizomes of Curculigo orchioides. Planta Medica. 1983;47(1):52-55.
Valls J, Richard T, Larronde F, Leblais V, Muller B, Delaunay JC, Monti JP, Ramawat KG, Mérillon JM. Two new benzylbenzoate glucosides from Curculigo orchioides. Fitoterapia. 2006;77(6):416-9.
Peng J, Jiang Y, Fan G, Chen B, Zhang Q, Chai Y, Wu Y. Optimization suitable conditions for preparative isolation and separation of curculigoside and curculigoside B from Curculigo orchioides by high-speed counter-current chromate-graphy. Separation and Purification Technology. 2006;52(1):22-28.
Anandakirouchenane E, Chandiran IS, Kadalmani, B. An investigation on preliminary phytochemical and safety profiles of methanolic root extract of Curculigo orchioides. Journal of pharmacy research. 2013;7:692-e696.
Raaman N, Selvarajan S, Balakrishnan D, Balamurugan G. Preliminary phyto-chemical screening, antimicrobial activity and nutritional analysis of methanol extract of Curculigo orchioides gaerten rhizomes. Journal of Pharmacy Research. 2009;2(7): 1201-1202.
Theng KB, Korpenwar AN. Preliminary phytochemical and physicochemical analysis of Curculigo orchioides gaertn. root tubers. Int. J. Bioassays. 2014;3(10): 3373-3375.
Brintha S, Rajesh S, Renuka R, Santhanakrishnan VP, Gnanam R. Phyto-chemical analysis and bioactivity prediction of compounds in methanolic extracts of Curculigo orchioides Gaertn. Journal of Pharmacognosy and Phytochemistry. 2017; 6(4):192-197.
Wang N, Zhao G, Zhang Y, Wang X, Zhao L, Xu P, Shou D. A network pharmacology approach to determine the active components and potential targets of Curculigo orchioides in the Treatment of Osteoporosis. Med Sci Monit. 2017a; 23:5113-5122.
Tan S, Xu J, Lai A, Cui R, Bai R, Li S, Liang W, Zhang G, Jiang S, Liu S, Zheng M, Wang W. Curculigoside exerts significant anti‑arthritic effects in vivo and in vitro via regulation of the JAK/STAT/ NF‑κB signaling pathway. Molecular Medicine Reports 19.3. 2019; 2057-2064.
Han J, Wan M, Ma Z, Hu C, Yi H. Prediction of targets of curculigoside a in osteoporosis and rheumatoid arthritis using network pharmacology and experimental verification. Drug Des Devel Ther. 2020; 14:5235-5250.
Zhang Q, Zhao L, Shen Y, He Y, Cheng G, Yin M, Zhang Q, Qin L. Curculigoside protects against excess-iron-induced bone loss by attenuating akt-foxo1-dependent oxidative damage to mice and osteoblastic MC3T3-E1 cells. Oxid Med Cell Longev. 2019;9281481.
Kang Z, Zhu H, Luan H, Han F, Jiang W. Curculigoside A induces angiogenesis through VCAM-1/Egr-3/CREB/VEGF signaling pathway. Neuroscience. 2014; 267:232-240.
Ooi DJ, Azmi NH, Imam MU, Alitheen NB, Ismail M. Curculigoside and polyphenol-rich ethyl acetate fraction of Molineria latifolia rhizome improved glucose uptake via potential mTOR/AKT activated GLUT4 translocation. Journal of Food and Drug Analysis. 2018;26(I4): 1253-1264.
Wang X, Zhang M, Zhang D, Wang S, Yan C. An O-acetyl-glucomannan from the rhizomes of Curculigo orchioides: Structural characterization and anti-osteoporosis activity in vitro. Carbohydr Polym., 2017b;174:48-56.
Venukumar MR, Latha MS. Antioxidant activity of Curculigo orchioides in carbon tetrachloride- induced hepatopathy in rats. Indian Journal of Clinical Biochemistry. 2002;17(2):80-7.
Um MY, Choi WH, Aan JY, Kim SR, Ha TY. Protective effect of Polygonum multiflorum Thunb on amyloid β- peptide 25–35 induced cognitive deficits in mice. J. Ethnopharmacol. 2006;104:144–148.
Yankner BA. Mechanisms of neuronal degeneration in Alzheimer’s disease. Neuron. 1996;16:921–932.
Wirths O, Multhaup G, Bayer TA. A modified beta-amyloid hypothesis: intraneuronal accumulation of the beta-amyloid peptide-the first step of a fatal cascade. J. Neurochem. 2004;91:513–520.
Liang DP, Han GC, Feng XM, Sun JY, Duan Y, Lei HX. Concerted perturbation observed in a hub network in Alzheimer’s disease. PLoS One. 2012;7:e40498.
Wightman EL. Conference on ‘Phyto-chemicals and health: new perspectives on plant-based nutrition’ Symposium 1: Phytochemicals and chronic disease. Potential benefits of phytochemicals against Alzheimer’s disease. Proceedings of the Nutrition Society. 2017;76:106–112.
Wu XY, Li JZ, Guo JZ, Hou BY. Ameliorative effects of curculigoside from Curculigo orchioides Gaertn on learning and memory in aged rats. Molecules (Basel, Switzerland). 2012;17(9):10108-10118.
Tian Z, Yu W, Liu HB, Zhang N, Li XB, Zhao MG, Liu SB. Neuroprotective effects of curculigoside against NMDA-induced neuronal excitoxicity in vitro. Food Chem Toxicol. 2012;50(11):4010-5.
Pratap GK, Rather SA, Shantaram M. In vitro anti-cholinesterase activity and mass spectrometric analysis of Curculigo orchioides Gaertn., rhizome extract. Analytical Chemistry Letters. 2020;10(4): 442-458.