COMBINATION OF CURCUMIN-β-CYCLODEXTRIN AND Aloe vera FOR LOWERING MOUTH ULCERS IN ACETIC ACID INDUCED RATS MODEL

Main Article Content

T. ARDY TANFIL
. SUTRIYO
https://orcid.org/0000-0002-9670-8155
ABDUL MUN’IM

Abstract

Aim and Background: Curcumin is a phytopolylphenol pigment found in the Curcuma longa plant. Curcumin is known to have several pharmacological properties. One of the pharmacological properties of curcumin is anti-inflammatory which is known to be used to treat stomatitis. Another plant with the same pharmacological properties is Aloe Vera, and Aloe Vera is a plant species with thick fleshy leaves from the genus Aloe. The aim of this study was to examine the anti-inflammatory effect of the combination of curcumin and aloe vera on recurrent aphthous stomatitis induced in rats.

Methods: The in vivo research model used five groups of rats, each group consisting of six male rats (Sprague Dawley). The criteria used were rats weighing 150-350 mg. All rats received 50% application of acetic acid induction to the mucosa.

Results: Topical application of curcumin: Aloe Vera (1: 2) combination showed better healing time than other combinations. Histopathological results also show that the curcumin: Aloe Vera (1: 2) combination provides an excellent healing effect.

Conclusion: The combination of Curcumin and Aloe Vera has shown positive results for the healing of oral ulcers induced by 50% acetic acid.

Keywords:
Stomatitis, curcumin, Aloe vera, inclusion complex

Article Details

How to Cite
TANFIL, T. A., SUTRIYO, ., & MUN’IM, A. (2021). COMBINATION OF CURCUMIN-β-CYCLODEXTRIN AND Aloe vera FOR LOWERING MOUTH ULCERS IN ACETIC ACID INDUCED RATS MODEL. PLANT CELL BIOTECHNOLOGY AND MOLECULAR BIOLOGY, 22(33-34), 405-414. Retrieved from https://ikprress.org/index.php/PCBMB/article/view/6420
Section
Original Research Article

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