ANTIBACTERIAL ACTIVITY OF SOME NEWLY SYNTHESIZED PYRAZOLINE DERIVATIVES
REEM S. NAJEM *
Department of Physiology, University of Tikrit, College of Veterinary Medicine, Biochemistry and Pharmacology, Iraq.
*Author to whom correspondence should be addressed.
Abstract
Pharmaceuticals and medical researchers keep investigating and working to find and synthesize new drugs to treat various types of pathological conditions, and also to overcome bacterial resistance to known antibiotics. Thirteen compounds were prepared referred as (C1-C13) from Parra aminoacetophenone after treated with sodium nitrite in the presence of hydrochloric acid to get diazonium salt. (C1). Then compound (C1) was retreated with different aromatic aldehydes (o- hydroxyl benzaldehyde, p- N, N-Di methyl benzaldehyde, - o chlorobenzaldehyde; o-nitro benzaldehyde), to get (C2- C5). Then these compound (C2- C5) were treated with furfural to get Compound (C6-C9). Compounds (C6- C9). And the later compounds were re treated again with hydrazine hydrate to get compounds (C10- C13). The chemical structures of the synthesized products were structurally confirmed on the basis of IR, characterized by (FT-IR) and (H-NMR) (10, 11) and melting points. The prepared compounds showed antibacterial activity against Staphylococcus aureus, E. coIi, KIebseilIa pneumonia, and Pseudomonas aeruginosa. The results of this work indicated a promises future for new antibacterial drugs.
Keywords: New pyrazoline derivatives, antibacterial chemicals, Parra aminoacetophenone