Journal of Biochemistry International

Women with Polycystic ovarian condition (PCOS) are reported to have obesity, which essentially influences the disorder's associated with insulin resistance, type 2 diabetes and cardiovascular disorders.  PCOS is a problem of endocrine abnormality in women between the ages of 14-44. In this paper we review on recent methods in genotyping of fat mass obesity (FTO) associated gene single nucleotide polymorphism and its relationship with PCOS. Literature survey indicated that in diagnosis of PCOS, blood tests were normally used in gene polymorphism investigations and DNA tests were used for genotyping examination. The quick detection by polymerase chain reaction (PCR) amplification is one of the commonest tests for identifying single nucleotide polymorphism (SNP) for FTO traits which is being routinely used to understand the frequency of SNP polymorphism in a given set of population in various countries and in ethnic groups. Worldwide, extensive investigations were carried out to analyze the genotypes of FTO traits and its association in understanding the etiology of PCOS. Such literature surveys are beneficial in developing simple PCOS diagnostic                         methods and finding new approaches in therapeutic interventions.  In this review paper, we highlight the genetic basis and importance of testing the FTO parameter in understanding the pathogenesis and the management of PCOS.