Exploring Novel Quinoxaline Derivatives as Potent Antiviral Agents: Synthesis and Biological Insights
Praphulla kumar singh *
Department of Chemistry, M.L.S.M College, Darbhanga Bihar, Pin 846004, India.
Babu Nand Choudhary
Department of Chemistry, M.L.S.M College, Darbhanga Bihar, Pin 846004, India.
*Author to whom correspondence should be addressed.
Abstract
The present study explores about synthesis and biological Insights of Novel Quinoxaline Derivatives as Potent Antiviral Agents. Viral infections are a big public health issue and we need antiviral agents. There has been a surge in interest regarding quinoxaline derivatives during recent years owing to the large array of therapeutic qualities they possess. A variety of analyses conducted between the years 2020 to 2024 have proved to be useful for any biological application including anticancer, antimicrobial, antiviral, anti-inflammatory and even antidiabetic. Due to their ability to treat a wide range of conditions, these compounds are promising candidates for subsequent drug design. The results of this study indicate that several quinoxaline-based compounds have promising antiviral activity against various viruses. The compounds showed the highest activity against influenza and herpes simplex viruses, which are major causes of morbidity worldwide. The presence of the quinoxaline ring, along with appropriate substitutions, appears to enhance antiviral activity. Additionally, the compounds were non-toxic to host cells, making them potential candidates for further development. In this study, we report quinoxaline derivatives as promising broad-spectrum antiviral agents with a special focus on their activity against respiratory viruses. This is an important area and it is in the general outline of the systematic review.
Keywords: Quinoxaline, antiviral agents, synthesis, characterization, biological evaluation, viral infections, in vitro assays, resistance